| Agent | Regimen[1,2] | Comments |
| Ampicillin | - 150 to 200 mg/kg per day in 4 divided doses (MAX 12 g/day)
| |
| Azithromycin | - 10 mg/kg once per day on days 1 and 2 of therapy (MAX 500 mg/day)
- 5 mg/kg once per day on subsequent days of therapy (MAX 250 mg/day)
| - Transition to oral therapy at 5 mg/kg per day as soon as clinically appropriate
|
| Cefazolin | - 100 to 150 mg/kg per day in 3 divided doses (MAX 12 g/day)
| - Limited data on doses >100 mg/kg per day
|
| Cefotaxime | - 150 mg/kg per day in 3 or 4 divided doses (MAX 8 g/day)
| - The 4-dose regimen should be used for severe infection or substantial local penicillin resistance
|
| Ceftaroline | - Age ≥2 months and <2 years: 8 mg/kg every 8 hours
- Age ≥2 and <18 years:
- Weight ≤33 kg: 12 mg/kg every 8 hours
- Weight >33 kg: 400 mg every 8 hours or 600 mg every 12 hours
- Age ≥18 years: 600 mg every 12 hours
| - Experience with ceftaroline in children with documented MRSA infection is limited
|
| Ceftriaxone | - 50 to 100 mg/kg per day in 1 or 2 divided doses (MAX 4 g/day)
| - The 100 mg/kg per day dose should be used only if local rates of penicillin resistance to Streptococcus pneumoniae are substantial (eg, ≥25%)
- The 2-dose regimen should be used for severe infection or if local rates of penicillin resistance to S. pneumoniae are substantial (eg, ≥25%)
|
| Clindamycin | - 30 to 40 mg/kg per day in 3 or 4 divided doses (MAX 2.7 g/day)
| |
| Doxycycline | - 4 mg/kg per day in 2 divided doses (MAX 200 mg/day)
| - Transition to oral therapy as soon as clinically appropriate
|
| Erythromycin | - 20 mg/kg per day in 4 divided doses (MAX 4 g/day)
| - Parenteral erythromycin is associated with phlebitis, prokinetic, and cardiotoxic effects (rare)
|
| Levofloxacin | - Age 6 months and <5 years: 16 to 20 mg/kg per day in 2 divided doses
- Age ≥5 to 16 years: 8 to 10 mg/kg once per day (MAX 750 mg)
| - Fluoroquinolones may prolong QTc interval; avoid use in patients with:[3]
- Long QT syndrome
- Hypokalemia or hypomagnesemia
- Organic heart disease (eg, congestive heart failure; requiring a class Ia antiarrhythmic drug*, particularly quinidine)
- Concurrent use of other medications that prolong the QTc interval
|
| Linezolid | - Age <12 years: 10 mg/kg every 8 hours (MAX 600 mg/dose)
- Age ≥12 years: 600 mg every 12 hours
| |
| Nafcillin | - 150 to 200 mg/kg per day in 4 or 6 divided doses (MAX 12 g/day)
| |
| Penicillin G | - For therapy: 200,000 to 250,000 units/kg per day in 4 or 6 divided doses (MAX 24 million units/day)
| |
| Vancomycin | - 40 to 60 mg/kg per day in 3 or 4 divided doses (MAX 4 g/day)¶
| |
