HLA alleles associated with susceptibility to DRESS^[1-7]

Drug	HLA/genetic variant	Population
Allopurinol	B*5801	Han Chinese, European, Thai, Korean
Carbamazepine	A*3101	European, Japanese, Han Chinese
Dapsone	B*1301	Chinese
Nevirapine	DRB1*01:01	African, Asian, European
	CW*8, B14	European
	B*35	Asian
Phenytoin	B13:01, B51:01	Han Chinese, Thai
Phenytoin	HLA-A*24:02	European
Vancomycin	A*32:01	European
Raltegravir	HLA-B*53:01	African, Hispanic

DRESS: drug reaction with eosinophilia and systemic symptoms; HLA: human leukocyte antigen.

References:

Phillips EJ, Chung WH, Mockenhaupt M, et al. Drug hypersensitivity: Pharmacogenetics and clinical syndromes. J Allergy Clin Immunol 2011; 127:S60.
Konvinse KC, Trubiano JA, Pavlos R, et al. HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms. J Allergy Clin Immunol 2019; 144:183.
Chen CB, Abe R, Pan RY, et al. An updated review of the molecular mechanisms in drug hypersensitivity. J Immunol Res 2018; 2018:6431694.
Oussalah A, Yip V, Mayorga C, et al. Genetic variants associated with T cell-mediated cutaneous adverse drug reactions: A PRISMA-compliant systematic review—An EAACI position paper. Allergy 2020; 75:1069.
Chang CJ, Chen CB, Hung SI, et al. Pharmacogenetic testing for prevention of severe cutaneous adverse drug reactions. Front Pharmacol 2020; 11:969.
Thomas M, Hopkins C, Duffy E, et al. Association of the HLA-B*53:01 allele with drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome during treatment of HIV infection with raltegravir. Clin Infect Dis 2017; 64:1198.
Lefebvre M, Walencik A, Allavena C, et al. Rate of DRESS syndrome with raltegravir and role of the HLA-B*53: 01 allele. J Acquir Immune Defic Syndr 2020; 85:e77.

Graphic 129631 Version 2.0

HLA alleles associated with susceptibility to DRESS[1-7]