Daptomycin breakpoints

Species	CLSI (2020)				EUCAST (2020)
Species	S	SDD	I	R	S	R
Enterococcus spp
Enterococcus faecium (only)	–	≤4	–	≥8	IE	IE
Enterococcus spp (other than E. faecium)	≤2	–	4	≥8	IE	IE
Staphylococcus spp
All staphylococci	≤1	–	–	–	≤1	>1
Streptococcus spp
Beta-hemolytic streptococci	≤1	–	–	–	≤1	>1
Viridans streptococci	≤1	–	–	–	–	–
Streptococcus pneumoniae	–	–	–	–	IE	IE

CLSI recommends that any Enterococcus spp, Staphylococcus spp, or beta-hemolytic Streptococcus spp which tests daptomycin nonsusceptible be referred to a reference laboratory for testing. Similarly, EUCAST recommends that any Staphylococcus spp or beta-hemolytic Streptococcus spp which tests daptomycin nonsusceptible be referred to a reference laboratory.
CLSI reference daptomycin dosing (for Enterococcus spp): tests susceptible: 6 mg/kg every 24 hours; tests susceptible dose dependent: 8 to 12 mg/kg every 24 hours.
EUCAST reference daptomycin dosing: standard dose: 4 mg/kg every 24 hours, high dose: 6 mg/kg every 24 hours.

CLSI: Clinical Laboratory and Standards Institute; EUCAST: European Committee on Antimicrobial Susceptibility Testing; S: susceptible; SDD: susceptible dose dependent; I: intermediate; R: resistant; IE: insufficient evidence.

Graphic 130617 Version 1.0

خرید پکیج

Daptomycin breakpoints