Name | Company/ developer | Platform | Indicated ages | Primary series | Booster dose* | Common side effects | Rare adverse effects |
BNT162b2 | Pfizer/BioNTech | mRNA | 6 months to 4 years | Three total doses¶:
| For those who received the monovalent vaccine for all primary series doses:
For those who received the bivalent vaccine as part of the primary series:
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5 to 11 years | Two 10 mcg doses 3 weeks apart¶Δ | One 10 mcg dose of the bivalent vaccine formulation (Pfizer-BioNTech COVID-19 vaccine, bivalent) at least 2 months following the last vaccine dose | |||||
12 years and older | Two 30 mcg doses 3 weeks apartΔ: Healthy individuals <65 years old can extend the interval to 8 weeks◊ | One 30 mcg dose of the bivalent vaccine formulation (Pfizer-BioNTech COVID-19 vaccine, bivalent) at least 2 months following the last vaccine dose | |||||
mRNA-1273 | Moderna | mRNA | 6 months to 5 years | Two 25 mcg doses 4 weeks apartΔ | One 10 mcg dose of the bivalent vaccine formulation (Moderna COVID-19 vaccine, bivalent) at least 2 months following the last vaccine dose (for individuals who received the primary series with Moderna COVID-19 vaccine) |
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6 to 11 years | Two 50 mcg doses 4 weeks apartΔ | One 25 mcg dose of the bivalent vaccine formulation (Moderna COVID-19 vaccine, bivalent) at least 2 months following the last vaccine dose | |||||
12 to 17 years | Two 100 mcg doses 4 weeks apartΔ: Healthy individuals <65 years old can extend the interval to 8 weeks◊ | One 25 mcg dose of the bivalent vaccine formulation (Moderna COVID-19 vaccine, bivalent) at least 2 months following the last vaccine dose | |||||
18 years and older | Two 100 mcg doses 4 weeks apartΔ: Healthy individuals <65 years old can extend the interval to 8 weeks◊ | One 50 mcg dose of the bivalent vaccine formulation (Moderna COVID-19 vaccine, bivalent) at least 2 months following the last vaccine dose | |||||
NVX-CoV2373 | Novavax | Recombinant protein, adjuvanted | 12 years and older | Two doses (5 mcg spike protein/50 mcg adjuvant) 3 weeks apart: Healthy individuals <65 years of age can extend the interval to 8 weeks◊ | Use is limited to individuals 18 years and older who have not received a booster dose and are unable or unwilling to receive an mRNA vaccine§:
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Ad26.COV2.S | Janssen/Johnson & Johnson | Replication-incompetent adenovirus 26 vector | 18 years and older | Use is limited to individuals who are unable or unwilling to receive other COVID-19 vaccines:
| Use is limited to individuals who are unable or unwilling to receive other COVID-19 vaccines:
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COVID-19: coronavirus disease 2019; CDC: Centers for Disease Control and Prevention.
* The CDC recommends a booster dose with a bivalent mRNA COVID-19 vaccine for all individuals ≥5 years old who had received a primary vaccine series (including those who had also received booster doses with the monovalent vaccine); recommendations for younger children depend on the primary vaccine series received. These recommendations replaced prior recommendations regarding first and second boosters with the monovalent vaccines. Monovalent mRNA vaccines are no longer recommended for booster doses.
¶ The formulations for children are specific to the age group and are distinct from that used in older individuals.
Δ For certain immunocompromised patients, additional doses are recommended as part of the primary series. The mRNA vaccines are given as a 3-dose series rather than a 2-dose series, with the third dose given at least 4 weeks after the second; for those who received a single dose of Ad26.COV2.S, an additional dose of an mRNA vaccine is given at least 4 weeks later. These additional doses do not replace the booster dose, which is also given for those age 5 years and older.
◊ Extending the interval to 8 weeks between vaccine doses may be preferable for adolescents and young adults (especially males age 12 to 39 years) who have no major comorbidities and do not need to maximize protection within a shorter period of time; it may be associated with a lower risk of myocarditis and slightly improved effectiveness.[6]
§ Individuals who received NVX-CoV2373 or Ad26.COV2.S for the primary series should receive a bivalent mRNA vaccine booster, either the Pfizer-BioNTech COVID-19 vaccine, bivalent (if ≥5 years old) or the Moderna COVID-19 vaccine, bivalent (if ≥6 years old).آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟