Version June 2024
Antibiotic treatment is indicated in all patients with a clinical or microbiologic diagnosis of pertussis who present within three weeks of cough onset because this is the highest risk period for transmission. After this period, cough may persist but is thought to be caused by tissue damage rather than active infection. Because shedding can persist for 6 weeks, the treatment window is extended for pregnant women who are near term to prevent transmission to neonates. We also extend the treatment window to 6 weeks in patients at increased risk for pertussis-related morbidity (eg, age ≥65, immunocompromise, chronic lung disease).
Because pertussis is highly transmissible, post-exposure prophylaxis is warranted within 21 days of exposure for household contacts as well as for close contacts who are at high risk for severe pertussis themselves or who are in close contact with others who at high risk for severe pertussis. Antibiotic regimens for prophylaxis are identical to those for treatment. Patients with B. pertussis infection should avoid contact with young children, infants, and other vulnerable populations until they have completed at least 5 days of antibiotic therapy. Refer to UpToDate text for detail.COPD: chronic obstructive pulmonary disease.
* The Centers for Disease Control and Prevention (CDC) recommends extending the treatment window in pregnant women but not other populations. Although limited, emerging data indicate that pertussis-related morbidity, including the risk for hospitalization, is highest in these specific subgroups.
¶ Azithromycin is the treatment of choice in pregnancy and is also the preferred agent for most other adults and adolescents. Clarithromycin can be used when azithromycin is not available. Dosage and duration of treatment for adults and adolescents are:آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
