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Ethambutol: Pediatric drug information

Ethambutol: Pediatric drug information
(For additional information see "Ethambutol: Drug information" and see "Ethambutol: Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Myambutol
Brand Names: Canada
  • Etibi
Therapeutic Category
  • Antitubercular Agent
Dosing: Pediatric
Mycobacterial infection, nontuberculous

Mycobacterial infection, nontuberculous: Limited data available:

Mycobacterium avium complex (MAC) infection in patients who are HIV-exposed/-infected:

Treatment: Note: Treatment should continue for at least 12 months and should be followed by secondary prophylaxis.

Infants and Children: Oral: 15 to 25 mg/kg/dose once daily as part of an appropriate combination regimen; maximum dose: 2,500 mg/dose (Ref).

Adolescents: Oral: 15 mg/kg/dose once daily as part of an appropriate combination regimen (Ref).

Secondary prophylaxis (chronic maintenance therapy):

Infants and Children: Oral: 15 to 25 mg/kg/dose once daily as part of an appropriate combination regimen; maximum dose: 2,500 mg/dose. May be discontinued if patient has completed ≥6 months of antiretroviral therapy and ≥12 months of MAC therapy, has no signs and symptoms of MAC, and achieves age-specific CD4 count goals for ≥6 months (age 2 to <6 years: >200 cells/mm3; ≥6 years: >100 cells/mm3) (Ref).

Adolescents: Oral: 15 mg/kg/dose once daily as part of an appropriate combination regimen. May be discontinued if patient has completed ≥12 months of MAC therapy, has no signs and symptoms of MAC, and has CD4 count >100 cells/mm3 in response to antiretroviral therapy for >6 months (Ref).

Pulmonary infection in patients with cystic fibrosis: Infants, Children, and Adolescents: Oral: 15 mg/kg/dose once daily as part of an appropriate combination regimen for ≥12 months after culture conversion (Ref).

Pulmonary infection in patients without cystic fibrosis: Infants, Children, and Adolescents: Oral: 20 mg/kg/dose once daily as part of an appropriate combination regimen for ≥12 months after culture conversion (Ref).

Tuberculosis disease [active tuberculosis]; drug-susceptible

Tuberculosis disease (active tuberculosis); drug-susceptible (excluding meningitis): Note: Treatment regimens for active tuberculosis typically consist of an initial 2-month intensive phase of a 4-drug regimen (including ethambutol, although a full 2 months of ethambutol may not be necessary), followed by a 2-drug regimen continuation phase (not including ethambutol); see guidelines for details and duration (Ref). Always use in combination with other antitubercular drugs. Any regimens using less than once-daily dosing should be administered as directly observed therapy (DOT).

Once-daily therapy: Note: The preferred frequency of administration is once daily; however, 5-days-per-week administration by DOT at the same daily dose is an acceptable alternative.

Infants, Children, and Adolescents, weighing <40 kg: Oral: 20 mg/kg/dose once daily; suggested range: 15 to 25 mg/kg/dose.

Children and Adolescents, weighing ≥40 kg: Note: Doses should be based on lean body weight for patients within a normal weight range for their height (optimal dosing in obesity has not been established).

40 to 55 kg: Oral: 800 mg once daily.

56 to 75 kg: Oral: 1,200 mg once daily.

76 to 90 kg: Oral: 1,600 mg once daily.

Three-times-weekly DOT:

Infants, Children, and Adolescents, weighing <40 kg: Oral: 50 mg/kg/dose 3 times weekly.

Children and Adolescents, weighing ≥40 kg: Note: Doses should be based on lean body weight for patients within a normal weight range for their height (optimal dosing in obesity has not been established).

40 to 55 kg: Oral: 1,200 mg 3 times weekly.

56 to 75 kg: Oral: 2,000 mg 3 times weekly.

76 to 90 kg: Oral: 2,400 mg 3 times weekly.

Twice-weekly DOT: Note: Regimen not generally recommended; associated with worse outcomes (treatment failure, relapse, and drug resistance) compared to daily dosing. Do not use in patients with HIV or those with smear-positive and/or cavitary disease; only for use in continuation phase (Ref).

Infants, Children, and Adolescents, weighing <40 kg: Oral: 50 mg/kg/dose twice weekly.

Children and Adolescents, weighing ≥40 kg: Note: Doses should be based on lean body weight for patients within a normal weight range for their height (optimal dosing in obesity has not been established).

40 to 55 kg: Oral: 2,000 mg twice weekly.

56 to 75 kg: Oral: 2,800 mg twice weekly.

76 to 90 kg: Oral: 4,000 mg twice weekly.

Tuberculosis disease [active tuberculosis]; drug-resistant

Tuberculosis disease (active tuberculosis); drug-resistant: Note: Duration should be individualized based on extent of disease, rapidity of culture conversion, clinical response, and toxicity; expert consultation for optimal regimen and duration of treatment is advised (Ref).

Infants, Children, and Adolescents: Oral: 20 to 25 mg/kg/dose once daily as part of an appropriate combination regimen (Ref).

Dosing: Kidney Impairment: Pediatric

Altered kidney function: Infants, Children, and Adolescents:

Note: Therapeutic drug monitoring should be utilized, when possible, in patients with severe kidney impairment or receiving renal replacement therapies to avoid drug accumulation and adverse effects, such as optic neuropathy (Ref). There are no clinical or pharmacokinetic data to support a renal dosage adjustment recommendation for dosing strategies other than once-daily dosing; dosing recommendations derived from adult guideline recommendations (Ref).

CrCl ≥30 mL/minute: No dosage adjustment necessary.

CrCl <30 mL/minute: Oral: 15 to 25 mg/kg/dose 3 times weekly.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling; use with caution.

Dosing: Adult

(For additional information see "Ethambutol: Drug information")

Mycobacterium avium complex disease

Mycobacterium avium complex disease (off-label use):

Pulmonary disease (nodular/bronchiectatic disease): Oral: 25 mg/kg 3 times weekly as part of an appropriate combination regimen; continue treatment until patient is culture negative on therapy for ≥1 year (Ref).

Pulmonary disease (severe nodular/bronchiectatic or cavitary disease): Oral: 15 mg/kg once daily as part of an appropriate combination regimen; continue treatment until patient is culture negative on therapy for ≥1 year (Ref).

Disseminated disease in patients with HIV, treatment and chronic maintenance therapy: Oral: 15 mg/kg once daily in combination with a macrolide (azithromycin or clarithromycin); may discontinue when patient has completed ≥12 months of therapy, has no signs/symptoms of M. avium complex disease, and has sustained (>6 months) CD4 count >100 cells/mm3 in response to antiretroviral therapy (ART). Note: Addition of a third or fourth drug should be considered for patients with advanced immunosuppression (CD4 count <50 cells/mm3), high mycobacterial loads (>2 log10 CFU/mL), or in the absence of effective ART (Ref).

Tuberculosis, drug-susceptible

Tuberculosis, drug-susceptible:

Note: Always administer in combination with other antitubercular drugs (Ref).

Dosing: Doses should be based on lean body weight for patients within a normal weight range for their height (optimal dosing for patients with obesity has not been established):

Once-daily therapy: Note: The preferred frequency of administration is once daily; however, 5-days-per-week administration by directly observed therapy (DOT) is an acceptable alternative (Ref).

40 to 55 kg: Oral: 800 mg (14.5 to 20 mg/kg).

56 to 75 kg: Oral: 1.2 g (16 to 21.4 mg/kg).

76 to 90 kg: Oral: 1.6 g (17.8 to 21.1 mg/kg).

Three-times-weekly DOT (Ref):

40 to 55 kg: Oral: 1.2 g (21.8 to 30 mg/kg).

56 to 75 kg: Oral: 2 g (26.7 to 35.7 mg/kg).

76 to 90 kg: Oral: 2.4 g (26.7 to 31.6 mg/kg).

Twice-weekly DOT (Ref):

40 to 55 kg: Oral: 2 g (36.4 to 50 mg/kg).

56 to 75 kg: Oral: 2.8 g (37.3 to 50 mg/kg).

76 to 90 kg: Oral: 4 g (44.4 to 52.6 mg/kg).

Regimens: Treatment regimens for pulmonary tuberculosis consist of an initial 2-month phase of a 4-drug regimen that includes ethambutol, followed by a continuation phase consisting of a 2-drug regimen (does not include ethambutol) of an additional 4 to 7 months; ethambutol frequency and dosing differs depending on treatment regimen selected; consult current drug-susceptible TB guidelines (Ref).

Tuberculosis, drug resistant

Tuberculosis, drug resistant (alternative agent): Note: Expert consultation for optimal regimen and duration of treatment is advised (Ref).

Low dose (companion drug): Oral: 15 mg/kg once daily (Ref).

High dose (bacteriostatic drug): Oral: 25 mg/kg once daily (Ref).

Dosing: Kidney Impairment: Adult

The renal dosing recommendations are based upon the best available evidence and clinical expertise. Senior Editorial Team: Bruce Mueller, PharmD, FCCP, FASN, FNKF; Jason A. Roberts, PhD, BPharm (Hons), B App Sc, FSHP, FISAC; Michael Heung, MD, MS.

Note: Therapeutic drug monitoring should be utilized, when possible, in patients with severe kidney impairment or on renal replacement therapies to avoid drug accumulation and adverse effects, such as optic neuropathy (Ref).

Altered kidney function (expert opinion derived from ATS/CDC/IDSA [Nahid 2016]; AST/CDC/ERS/IDSA [Nahid 2019]; HHS [OI Adult 2020]; WHO 2014b):

CrCl ≥30 mL/minute: No dosage adjustment necessary.

CrCl <30 mL/minute: If usual recommended dose is administered once daily, then do not adjust the dose, but only administer 3 times weekly (eg, if usual dose is 15 mg/kg once daily, then administer 15 mg/kg 3 times weekly; if usual dose is 25 mg/kg once daily, then administer 25 mg/kg 3 times weekly). Since there are no clinical or pharmacokinetic data to support a renal dosage adjustment recommendation for dosing strategies other than once daily dosing (eg, the directly observed therapy [DOT] twice-weekly or 3-times–weekly dosing described in patients with normal kidney function) use of these dosing strategies are not recommended.

Hemodialysis, intermittent (thrice weekly): Dialyzable (extent not well characterized) (Ref): Dose as CrCl <30 mL/minute; administer after hemodialysis on dialysis days (Ref). Use with caution and close monitoring, as hemodialysis patients may develop optic adverse effects, even with properly adjusted doses (Ref).

Peritoneal dialysis: Likely dialyzable, but not considered a major route of removal (Ref): Dose as for CrCl <30 mL/minute (Ref). Use with caution and close monitoring (Ref).

CRRT: Drug clearance is dependent on the effluent flow rate, filter type, and method of renal replacement. Recommendations are based on high-flux dialyzers and effluent flow rates of 20 to 25 mL/kg/hour (or ~1,500 to 3,000 mL/hour) unless otherwise noted. Appropriate dosing requires consideration of adequate drug concentrations (eg, site of infection). Close monitoring of response and adverse effects (eg, optic neuropathy) due to drug accumulation is important.

Note: Has not been studied in patients undergoing CRRT; some drug removal is expected but relatively large Vd will likely prevent substantial removal (Ref).

Dose as for CrCl <30 mL/minute; utilize therapeutic monitoring when possible to guide further dose adjustments (Ref).

PIRRT (eg, sustained, low-efficiency diafiltration): Note: Drug clearance is dependent on the effluent flow rate, filter type, and method of renal replacement. Appropriate dosing requires consideration of adequate drug concentrations (eg, site of infection). Close monitoring of response and adverse effects (eg, optic neuropathy) due to drug accumulation is important.

Note: Limited data available in patients undergoing PIRRT; some drug removal is expected, but relatively large Vd will likely prevent substantial removal (Ref). Recommendations assume daily PIRRT sessions.

Dose as for CrCl <30 mL/minute; on PIRRT days, administer after the PIRRT session (Ref). Utilize therapeutic monitoring, when possible, to guide further dose adjustments (Ref).

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling; use with caution.

Adverse Reactions

The following adverse drug reactions are derived from product labeling unless otherwise specified. Adverse reactions may be reported as part of combination therapy.

Postmarketing:

Dermatologic: Dermatitis, erythema multiforme, lichenoid eruption (Grossman 1995), pruritus (Chung 2022), skin lesion (bullous) (Kollipara 2022), skin rash (Chung 2022), Stevens-Johnson syndrome (Chung 2022), toxic epidermal necrolysis (Pegram 1981)

Endocrine & metabolic: Acute gout attack, increased uric acid (Chung 2022)

Gastrointestinal: Abdominal pain (Chung 2022), anorexia (Chung 2022), gastric distress, nausea (Chung 2022), vomiting (Chung 2022)

Hematologic & oncologic: Agranulocytosis (Moon 2015), eosinophilia (Wong 1994), leukopenia (Chung 2022), neutropenia (Wong 1994), thrombocytopenia (Chung 2022)

Hepatic: Abnormal hepatic function tests (Chung 2022), hepatotoxicity

Hypersensitivity: Drug reaction with eosinophilia and systemic symptoms (Kapur 2019), hypersensitivity reaction (including anaphylaxis, nonimmune anaphylaxis) (Cernadas 2013)

Nervous system: Confusion, disorientation, dizziness (Chung 2022), headache (Chung 2022), malaise (Chung 2022), peripheral neuritis (numbness, tingling of extremities), psychotic symptoms (including hallucination) (Prasad 2008)

Neuromuscular & skeletal: Arthralgia (Chung 2022), subacute cutaneous lupus erythematosus (Huang 2022)

Ophthalmic: Optic neuropathy (including optic neuritis and retrobulbar neuritis) (Chan 2006; Kyncl 2023), visual disturbance (including color blindness, decreased visual acuity [unilateral or bilateral], irreversible blindness, scotoma) (Kyncl 2023)

Renal: Acute interstitial nephritis (García-Martín 1991), acute kidney injury (Kwon 2004)

Respiratory: Pneumonitis (including eosinophilic pneumonitis) (Saha 2013; Takami 1997), pulmonary infiltrates (with or without eosinophilia) (Wong 1995)

Miscellaneous: Fever (Chung 2022)

Contraindications

Hypersensitivity to ethambutol or any component of the formulation; optic neuritis (risk vs benefit decision); use in young children, unconscious patients, or any other patient who may be unable to discern and report visual changes.

Warnings/Precautions

Concerns related to adverse effects:

• Hepatic toxicity: Has been reported, possibly due to concurrent therapy.

• Optic neuritis: May cause optic neuritis (unilateral or bilateral), resulting in decreased visual acuity or other vision changes. Discontinue promptly in patients with changes in vision, color blindness, or visual defects (effects normally reversible, but reversal may require up to a year). Irreversible blindness has been reported.

Disease-related concerns:

• Ocular disease: Evaluation of visual acuity changes may be more difficult in patients with cataracts, optic neuritis, diabetic retinopathy, and inflammatory conditions of the eye; consideration should be given to whether or not visual changes are related to disease progression or effects of therapy.

• Renal impairment: Use with caution in patients with renal impairment; dosage modification recommended.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Tablet, Oral, as hydrochloride:

Myambutol: 400 mg [scored]

Generic: 100 mg, 400 mg

Generic Equivalent Available: US

Yes

Pricing: US

Tablets (Ethambutol HCl Oral)

100 mg (per each): $0.46 - $0.59

400 mg (per each): $0.72 - $1.79

Tablets (Myambutol Oral)

400 mg (per each): $0.98

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Tablet, Oral, as hydrochloride:

Etibi: 100 mg, 400 mg [contains corn starch, fd&c blue #1 (brill blue) aluminum lake, quinoline (d&c yellow #10) aluminum lake]

Administration: Pediatric

Oral: Administer with or without food; if GI upset occurs, administer with food. Tablet may be crushed for administration in patients who cannot swallow tablets; mix in a small amount of water or food (eg, grape jelly, sugar-free chocolate pudding) and administer immediately; may be administered via mouth or nasogastric tube (Ref).

Administration: Adult

Oral: Administer with or without food.

Storage/Stability

Store at controlled room temperature of 20°C to 25°C (68°F to 77°F).

Use

Treatment of pulmonary tuberculosis in combination with other antituberculosis agents (FDA approved in ages ≥13 years and adults); has also been used for the treatment of other mycobacterial diseases in combination with other antimycobacterial agents.

Medication Safety Issues
Sound-alike/look-alike issues:

Myambutol may be confused with Nembutal

Metabolism/Transport Effects

Substrate of OCT1, OCT2

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Aluminum Hydroxide: May decrease the serum concentration of Ethambutol. Management: Avoid concurrent administration of ethambutol and aluminum hydroxide. If coadministration cannot be avoided administer ethambutol first and then wait at least 4 hours before administering aluminum hydroxide-containing products. Risk D: Consider therapy modification

Bacillus clausii: Antibiotics may diminish the therapeutic effect of Bacillus clausii. Management: Bacillus clausii should be taken in between antibiotic doses during concomitant therapy. Risk D: Consider therapy modification

BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Risk X: Avoid combination

BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Risk C: Monitor therapy

Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Risk X: Avoid combination

Fecal Microbiota (Live) (Oral): May diminish the therapeutic effect of Antibiotics. Risk X: Avoid combination

Fecal Microbiota (Live) (Rectal): Antibiotics may diminish the therapeutic effect of Fecal Microbiota (Live) (Rectal). Risk X: Avoid combination

Immune Checkpoint Inhibitors (Anti-PD-1, -PD-L1, and -CTLA4 Therapies): Antibiotics may diminish the therapeutic effect of Immune Checkpoint Inhibitors (Anti-PD-1, -PD-L1, and -CTLA4 Therapies). Risk C: Monitor therapy

Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Risk C: Monitor therapy

Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Risk D: Consider therapy modification

Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Avoid use of live attenuated typhoid vaccine (Ty21a) in patients being treated with systemic antibacterial agents. Postpone vaccination until 3 days after cessation of antibiotics and avoid starting antibiotics within 3 days of last vaccine dose. Risk D: Consider therapy modification

Reproductive Considerations

Evaluate pregnancy status prior to treatment of multidrug-resistant tuberculosis in females of reproductive potential. Females of reproductive potential should use effective contraception during treatment for multidrug-resistant tuberculosis (Esmail 2018).

Pregnancy Considerations

Ethambutol crosses the placenta (Shneerson 1979).

In 1 case report, ethambutol placental concentrations were similar to those in the maternal plasma. Ethambutol was also present in the cord blood and amniotic fluid (Shneerson 1979).

Ophthalmic abnormalities have been reported in infants born to patients receiving ethambutol as a component of antituberculosis therapy. Tuberculosis (TB) disease (active TB) is also associated with adverse fetal outcomes including intrauterine growth restriction, low birth weight, preterm birth, and perinatal death (Esmail 2018; Miele 2020) as well as adverse maternal outcomes, including increased risks for anemia and cesarean delivery. Placental transmission may rarely occur with active maternal disease (Miele 2020).

Due to the risks of untreated TB, ethambutol is recommended as part of the initial treatment regimen of drug-susceptible active TB when the probability of maternal disease is moderate to high (ATS/CDC/IDSA [Nahid 2016]).

Ethambutol may also be used to treat multidrug-resistant TB. The treatment of multidrug-resistant TB in patients who are pregnant should be individualized; evidence to support a specific regimen is not available (ATS/CDC/ERS/IDSA [Nahid 2019]; WHO 2020).

Pregnancy-induced physiologic changes do not alter the pharmacokinetic properties of ethambutol in a clinically significant way; dose adjustment is not needed in patients who are pregnant (Abdelwahab 2020).

Monitoring Parameters

Baseline and periodic (monthly) examination of visual acuity and color discrimination in patients receiving >15 mg/kg/day; baseline and periodic renal, hepatic, and hematologic function tests. Young children may be unable to report vision changes; monitor for eye rubbing or excessive blinking, or decrease in ability to grasp small objects (Loeffler 2022). Therapeutic drug monitoring (if available) should be considered in certain scenarios (eg, altered kidney function, possible malabsorption).

Reference Range

Ethambutol concentration monitoring is not routine but should be considered in certain scenarios (eg, altered kidney function, possible malabsorption) (Alsultan 2014; BTS [Haworth 2017]). The following target concentrations have been described in pharmacokinetic studies, but risks and benefits of achieving targets in pediatric patients have not been determined; pharmacokinetic studies indicate that overall clinical responses remain high despite a low likelihood of pediatric patients attaining these targets (Chabala 2022; Tikiso 2022; Turkova 2022).

Cmax (2 hours after dose): 2 to 6 mg/L (Alsultan 2014; BTS [Haworth 2017]; Chabala 2022; Tikiso 2022).

AUC24: 16 to 29 mg•hour/L (Alsultan 2014; Chabala 2022; Tikiso 2022).

Mechanism of Action

Inhibits arabinosyl transferase resulting in impaired mycobacterial cell wall synthesis

Pharmacokinetics (Adult Data Unless Noted)

Absorption: ~80%

Distribution: Widely throughout body; concentrated in kidneys, lungs, saliva, and red blood cells

CSF:blood level ratio: Normal meninges: 0%; Inflamed meninges: 25%

Protein binding: 20% to 30%

Metabolism: Hepatic (20%) to inactive metabolite

Half-life elimination: 2.5 to 3.6 hours; End-stage renal disease: 7 to 15 hours

Time to peak, serum: 2 to 4 hours

Excretion: Urine (~50% as unchanged drug, 8% to 15% as metabolites); feces (~20% as unchanged drug)

Pharmacokinetics: Additional Considerations (Adult Data Unless Noted)

Pediatric: Clearance increases to 50% of full value by 2 months of age and reaches 99% of full value by 3 years of age (Tikiso 2022).

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Myambutol;
  • (AR) Argentina: Etambutol | Etambutol northia | Etambutol richet;
  • (AT) Austria: Etibi | Myambutol;
  • (AU) Australia: Myambutol;
  • (BD) Bangladesh: Etb | Ethamben | Fiambutol | Mycobac | Servambutol | Sural;
  • (BE) Belgium: Myambutol;
  • (BG) Bulgaria: Etambutol | Ethambutol ds;
  • (BR) Brazil: Furp etambutol;
  • (CH) Switzerland: Ethambutol labatec | Myambutol;
  • (CN) China: Ethambutol | Ethambutol hydrochloride | Sural;
  • (CO) Colombia: Ecox;
  • (CZ) Czech Republic: Sural;
  • (DE) Germany: Emb | Emb fatol | Myambutol;
  • (DO) Dominican Republic: Luframbutol;
  • (EC) Ecuador: Etambutol | Ethambutol | Myambutol;
  • (EE) Estonia: Emb fatol | Ethambutol | Oributol | Syntomen;
  • (EG) Egypt: Etibi;
  • (ET) Ethiopia: Ethambutol;
  • (FI) Finland: Etbutol | Ethambutol orion | Myambutol | Oributol | Stambutol;
  • (FR) France: Dexambutol | Ethambutol | Myambutol;
  • (GB) United Kingdom: Ethambutol | Ethambutol kent;
  • (GR) Greece: Myambutol;
  • (HK) Hong Kong: Emb fatol | Ethambutec | Ethambutol | Lambutol | Myambutol;
  • (HR) Croatia: Etambutol | Sural;
  • (HU) Hungary: Sural;
  • (ID) Indonesia: Arsitam | Bacbutol | Butolex | Cetabutol | Corsabutol | Decabutol | Dexabutol | Ethambutol | Ethambutol Bernofarm | Etibi | Kalbutol | Myambutol | Ottobutol | Primbutol | Propar | Protibi | Santibi | Tibigon | Tibitol;
  • (IE) Ireland: Ethambutol;
  • (IL) Israel: Myambutol;
  • (IN) India: Albutol | Anacox-e | Biobutol | Butacox | Cavibutol | Colbutol | Combutol | Concox | Ebutol | Ecox | Ethambutol | Ethatol | Fairbutol | Koxi | Koxylar | Lifebutol | Lincambutol | Ly butol | Marcobutol | Myambutol | Mycobact | Mycobutol | Mycostat | Ranbetol | Rptol | Sainbutol | Sunibutol | Synbutol | Themibutol | Tibitol | Tolbin | Ulticox | Ultiflox | Zytham;
  • (IT) Italy: Etapiam | Miambutol;
  • (JP) Japan: Ebutol | Esanbutol | Esanbutol hexal;
  • (KE) Kenya: Ecox | Etham;
  • (KR) Korea, Republic of: Esanbutol | Ethambutol | Korus ethambutol hcl | Myambutol | Tambutol | Tutol | Unibutol;
  • (LB) Lebanon: Myambutol;
  • (LT) Lithuania: Emb fatol | Etambulol atb | Etambutol | Ethambutol | Ly butol | Myambutol | Mycobutol | Sural;
  • (LU) Luxembourg: Myambutol;
  • (LV) Latvia: Ethambutol | Ly butol | Mycobutol | Sural;
  • (MA) Morocco: Ethambutol Pharma;
  • (MX) Mexico: Brunibutol | Dovalem | Etambutol | Tambutec;
  • (MY) Malaysia: Ambutol | Ebutol | Ecox | Ethambutol | Ethol | Etinol;
  • (NG) Nigeria: Ethambutol | Surelife ethambutol;
  • (NL) Netherlands: Ethambutol Dihcl Fisher | Myambutol;
  • (NO) Norway: Emb fatol;
  • (NZ) New Zealand: Apo-ethambutol | Emb fatol;
  • (PE) Peru: Etambutol | Tibutol;
  • (PH) Philippines: E Tol | Ethambin | Ethambutol hydrochloride | Hambutol | Odetol | Usa-ethambutol;
  • (PK) Pakistan: Abbutol | Ambutol | Butal | Ethambutol | Etibi | Myambutol | Pire 1 | Schazobutol | Ubutol;
  • (PR) Puerto Rico: Ethambutol HCL | Ethambutol hydrochloride | Myambutol;
  • (PT) Portugal: Etambutol | Turresis;
  • (RO) Romania: Etambutol | Etambutol Atb;
  • (RU) Russian Federation: Combutol | Ebutol | Ecox | Emb fatol | Ethambusin | Ethambutol | Ethambutol Akri | Ethambutol stada | Li butol | Ly butol | Mycobutol;
  • (SA) Saudi Arabia: Myambutol;
  • (SG) Singapore: Ebutol | Ethambutol | Myambutol;
  • (SI) Slovenia: Emb fatol | Etambutol;
  • (SK) Slovakia: Sural;
  • (TH) Thailand: Ambutol | Asiabutal | AT B | Conbutol | Dexambutol | Etham | Ethambutol | Ethbutol | Etibi | Lambutol | Mobutol | Myambutol | Servambutol | Tibitab | Tibitol | Tobutol | Tubertham;
  • (TN) Tunisia: Ethambutol;
  • (TR) Turkey: Dimbutol | Ethambutol | Miambutol;
  • (TW) Taiwan: Ambutol | E butol | Ebutol | Epbutol | Ethambutol | Ethambutol "p.l." | Etibi | Feramtol | Matamfe | Myambutol | Myambutol I/P | Winbutol;
  • (UA) Ukraine: Bruambutol | Combutol | Ecox | Enbutol | Ethambutol;
  • (UG) Uganda: Etham;
  • (UY) Uruguay: Myambutol;
  • (VN) Viet Nam: Vemarol;
  • (ZA) South Africa: Dyna ethambutol | Ethambutol | Myambutol | Rolab-ethambutol;
  • (ZM) Zambia: Ecox;
  • (ZW) Zimbabwe: Ethambutol | Sandoz ethambutol | Thamtol
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