MR 1.5T imaging on fifth day of a 29-year-old male who traveled to high altitude from sea level within 1 day. Patient developed typical symptoms of HACE (progressive confusion) at 9610 feet (2930 meters). Axial FLAIR (A, D), diffusion (B, E), and ADC map (C, F) images demonstrate hyperintensity and restricted diffusion in the entire corpus callosum and patchy areas of bilateral subcortical white matter.