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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : -24 مورد

Risk factors for invasive bacterial illness* in febrile infants younger than 90 days of age

Risk factors for invasive bacterial illness* in febrile infants younger than 90 days of age
Age <28 days
Ill appearance
Rectal temperature ≥38.5°C (101.3°F; infants 22 to 60 days old only)
Prematurity (gestational age <37 weeks)
Received antibiotics within:
  • Neonates: 7 days of presentation
  • Infants 29 to 60 days old: 3 days of presentation
Comorbidities or chronic illness (any one of the following):
  • Perinatal course complicated by surgery or infection
  • Medically fragile (technology dependent or require specific therapies to sustain life)Δ
  • Documented or suspected immune compromise
  • Congenital or chromosomal abnormality
Maternal risk for early-onset sepsis (neonates <14 days only, any one of the following):
  • Peripartum fever
  • Prolonged rupture of membranes
  • Vaginal culture positive for group B Streptococcus
Focal infection◊

* Invasive bacterial illness (IBI) primarily refers to bacteremia and meningitis.

¶ For well-appearing neonates 22 to 28 days old and infants 29 to 60 days old in settings where procalcitonin measurements are not readily available, a temperature ≥38.6°C may also be used as an inflammatory marker that raises the risk of IBI along with absolute neutrophil count, or C-reactive protein (refer to UpToDate content on evaluation and management of the febrile neonate and the febrile infant 29 to 60 days of age).

Δ Examples include home ventilator, home oxygen, or total parenteral nutrition.

◊ Focal infections associated with an increased risk of IBI in febrile young infants include cellulitis, abscess, pneumonia, osteomyelitis, bacterial arthritis, and omphalitis.
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