Trial | Population | N | Design | Results |
MSLT-I[1] | Primary melanoma, clinically node negative | 2001 | Randomized to wide excision alone or wide excision with SLN biopsy and completion dissection for positive SLN | - SLN strong prognostic indication
- No significant melanoma-specific survival benefit, but intermediate-thickness node positive patients with better MSS
- Improved RFS for SLN group
|
MSLT-II[2] | Patients with SLN metastases | 1939 | Randomized to completion dissection or nodal observation | - No difference in MSS
- More complete staging with CLND
- Slight improvement in DFS with CLND
|
DeCOG-SLT[3,4] | Patients with SLN metastases | 483 | Randomized to completion dissection or nodal observation | - No difference in MSS or DFS
|