EEG | | - Interictal: Mild background slowing
| - Interictal:
- Persistent focal slowing or moderate or greater background slowing not limited to the postictal period
- Burst suppression pattern
- Hypsarhythmia
- Ictal: Lack of EEG correlate with clinical symptoms
|
Development at onset | | - A history of prior acute symptomatic seizures including intracranial infection, ischemic or hemorrhagic stroke, hypoxic-ischemic brain injury, significant metabolic disturbances
| |
Imaging | | | - Neuroimaging documenting a causal lesion for seizures
|
Course of illness | | - Mild neurodevelopmental delay long-term
- Lack of remission of epilepsy by age 2 years
- Drug-resistant epilepsy
| - Moderate to severe neurodevelopmental disability
|
Syndrome without laboratory confirmation: In resource-limited regions, self-limited neonatal-infantile epilepsy (SeLFNIE) can be diagnosed without EEG and MRI in a neonate with a family history suggestive of familial self-limited neonatal-infantile epilepsy who meets all other mandatory and exclusionary clinical criteria and has no alerts. However, the clinical history of affected family members should be consistent with the expected course for SeLFNIE, and careful follow-up of the patient is required to ensure that their course is also consistent with this syndrome. |