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2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for Takayasu arteritis

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for Takayasu arteritis
Considerations when applying these criteria
  • These classification criteria should be applied to classify the patient as having Takayasu arteritis when a diagnosis of medium-vessel or large-vessel vasculitis has been made
  • Alternate diagnoses mimicking vasculitis should be excluded prior to applying the criteria
Absolute requirements
Age ≤60 years at time of diagnosis
Evidence of vasculitis on imaging*
Additional clinical criteria
Female sex +1
Angina or ischemic cardiac pain +2
Arm or leg claudication +2
Vascular bruit +2
Reduced pulse in upper extremityΔ +2
Carotid artery abnormality +2
Systolic blood pressure difference in arms ≥20 mmHg +1
Additional imaging criteria
Number of affected arterial territories (select one)§
  • One arterial territory
+1
  • Two arterial territories
+2
  • Three or more arterial territories
+3
Symmetric involvement of paired arteries¥ +1
Abdominal aorta involvement with renal or mesenteric involvement +3
Sum the scores for 10 items, if present. A score of ≥5 points is needed for the classification of Takayasu arteritis.

* Evidence of vasculitis in the aorta or branch arteries must be confirmed by vascular imaging (eg, computed tomographic/catheter-based/magnetic resonance angiography, ultrasound, positron emission tomography).

¶ Bruit detected by auscultation of a large artery, including the aorta, carotid, subclavian, axillary, brachial, renal, or iliofemoral arteries.

Δ Reduction or absence of pulse by physical examination of the axillary, brachial, or radial arteries.

◊ Reduction or absence of pulse of the carotid artery or tenderness of the carotid artery.

§ Number of arterial territories with luminal damage (eg, stenosis, occlusion, or aneurysm) detected by angiography or ultrasonography from the following 9 territories: thoracic aorta, abdominal aorta, mesenteric, left or right carotid, left or right subclavian, left or right renal arteries.

¥ Bilateral luminal damage (stenosis, occlusion, or aneurysm) detected by angiography or ultrasonography in any of the following paired vascular territories: carotid, subclavian, or renal arteries.

‡ Luminal damage (stenosis, occlusion, aneurysm) detected by angiography or ultrasonography involving the abdominal aorta and either the renal or mesenteric arteries.
From: Grayson PC, Ponte C, Suppiah R, et al. 2022 American College of Rheumatology/EULAR classification criteria for Takayasu arteritis. Ann Rheum Dis 2022; 81:1654. Copyright © 2022 The Authors (or their employers). Reproduced with permission from BMJ Publishing Group Ltd.
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