Regimen | Comments |
Dicloxacillin 1 g orally every 6 hours plus Rifampin 600 mg orally every 12 hours |
|
Linezolid 600 mg orally every 12 hours plus Rifampin* 600 mg orally every 12 hours |
|
Ciprofloxacin 750 mg orally every 12 hours plus Rifampin 300 mg orally every 8 hours |
|
Trimethoprim-sulfamethoxazole 2 double-strength tablets (160 mg/800 mg per tablet) orally every 12 hours |
|
Doxycycline 100 mg orally every 12 hours |
|
Dalbavancin 1000 mg IV loading dose, then 500 mg IV once weekly or 1500 mg IV loading dose, then 1000 mg IV once every other week |
|
Oritavancin 1200 mg IV weekly |
|
MSSA: methicillin-susceptible S. aureus; POET: Partial Oral Versus Intravenous Antibiotic Treatment trial; SSRI: selective serotonin reuptake inhibitor; MAOI: monoamine oxidase inhibitor; ECG: electrocardiogram; MRSA: methicillin-resistant S. aureus; IE: infectious endocarditis; IV: intravenously.
* In areas where fusidic acid is available, fusidic acid (750 mg orally every 12 hours) may be used instead of rifampin.
¶ Refer to the UpToDate topic on linezolid for further discussion.Adapted from: Baddour LM, Weimer MB, Wurcel AG, et al. Management of infective endocarditis in people who inject drugs: A scientific statement from the American Heart Association. Circulation 2022; 146:e187.
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