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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : -5 مورد

Clinical findings of POEMS syndrome

Clinical findings of POEMS syndrome
Characteristic % Affected*
Polyneuropathy 100
Organomegaly 45 to 85
  • Hepatomegaly
 23 to 78
  • Splenomegaly
 22 to 70
  • Lymphadenopathy
 26 to 74
  • Castleman disease
 11 to 25
Endocrinopathy 67 to 89
  • Gonadal axis abnormality
 55 to 89
  • Adrenal axis abnormality
 16 to 33
  • Increased prolactin value
 5 to 20
  • Gynecomastia or galactorrhea
 12 to 18
  • Diabetes mellitus
 3 to 36
  • Hypothyroidism
 9 to 67
Monoclonal plasma cell dyscrasia 100
  • M-protein on serum protein electrophoresis
 24 to 55
Skin changes 68 to 93
  • Hyperpigmentation
 25 to 93
  • Acrocyanosis and plethora
 19 to 46
  • Hemangioma/telangiectasia
 9 to 35
  • Hypertrichosis
 20 to 74
  • Thickening
 5 to 43
Papilledema 29 to 64
Extravascular volume overload 29 to 89
  • Peripheral edema
 24 to 89
  • Ascites
 6 to 54
  • Pleural effusion
 3 to 43
  • Pericardial effusion
 1 to 64
Bone lesions 27 to 97
Thrombocytosis 34 to 88
Polycythemia 12 to 19
Clubbing 5 to 49
Decreased DLCO >15
Pulmonary hypertension 36
Weight loss >10 lb 37 to 41
Fatigue 22 to 31

POEMS: polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes; DLCO: diffusing capacity of carbon monoxide.

* Percentages are based on the total number of patients in the series.

¶ In both the Takasuki and Nakanishi series, only 75% of patients had a documented plasma cell disorder, which defies the current definition for POEMS syndrome. As these are among the earliest series describing the syndrome, they are included.
References:
  1. Takatsuki K, Sanada I. Plasma cell dyscrasia with polyneuropathy and endocrine disorder: clinical and laboratory features of 109 reported cases. Jpn J Clin Oncol 1983; 13:543.
  2. Nakanishi T, Sobue I, Toyokura Y, et al. The crow-Fukase syndrome: a study of 102 cases in Japan. Neurology 1984; 34:712.
  3. Soubrier MJ, Dubost JJ, Sauvezie BJ. POEMS syndrome: a study of 25 cases and a review of the literature. French study group on POEMS syndrome. Am J Med 1994; 97:543.
  4. Li J, Zhou DB, Huang Z, et al. Clinical characteristics and long-term outcome of patients with POEMS syndrome in China. Ann Hematol 2011; 90:819.
  5. Dispenzieri A, Kyle RA, Lacy MQ, et al. POEMS syndrome: definitions and long-term outcome. Blood 2003; 101:2496.
  6. Ghandi GY, Basu R, Dispenzieri A, et al. Endocrinopathy in POEMS syndrome: the Mayo Clinic experience. Mayo Clin Proc 2007; 82:836.
  7. Keddie S, Foldes D, Caimari F, et al. Clinical characteristics, risk factors, and outcomes of POEMS syndrome: A longitudinal cohort study. Neurology 2020; 95:e268.
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