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Strategies for adjusting insulin doses for children with type 1 diabetes when crossing multiple time zones

Strategies for adjusting insulin doses for children with type 1 diabetes when crossing multiple time zones
If using insulin pump
  • On arrival, adjust time setting on the pump to the local time. No other adjustments are needed.
If using multiple daily injections
Brief stay
  • Administer the basal insulin at the same time that it would be administered in the home time zone.
Longer stay
  • Use gradual adjustment:
    • Adjust the timing of basal insulin injection by 2 hours each day to a time that is more appropriate for the new time zone.
  • or
  • Switch to insulin degludec:
    • Insulin degludec has very long duration of action, so no time adjustment is needed.
    • Degludec should be started at least 1 week to 10 days before the planned trip so that dose adjustments can be made.
    • When making this transition, the total basal insulin dose should be decreased by approximately 20% and then adjusted as needed.
If using a fixed-dose regimen with NPH*
  • Monitor blood glucose.
  • Continue the usual regimen until ready to depart from the home time zone.
  • If the child develops hyperglycemia before the next-scheduled administered NPH dose, treat with additional doses of rapid- and short-acting insulin.
  • Give the next dose of insulin (with the usual doses of NPH and other insulins) before the appropriate meal in the new time zone (typically at breakfast or dinner).
Other guidance
  • Transport insulin in carry-on luggage; refrigerate in a cooler (do not freeze) during long trips.
  • Carry food and carbohydrate preparations (eg, glucose tablets) on the plane to ensure ready access when needed.
This table outlines several options for adjusting basal insulin dosing when crossing multiple time zones. In addition to changing time zones, travel often involves changes in the child's level of activity and meal schedule and composition. With any of these methods, blood glucose should be checked regularly and further adjustments made in basal and rapid-acting insulin boluses as needed.

NPH: neutral protamine hagedorn.

* Fixed-dose regimens with NPH are more commonly used in limited-resource settings.
Graphic 141429 Version 1.0

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