Respiratory syncytial virus (RSV) prevention: Choosing between maternal vaccination and newborn immunoprophylaxis

IM: intramuscular; RSV: respiratory syncytial virus.

* In the northern hemisphere, vaccination should occur from September through January, so that newborns are protected during RSV season, which is from October through late March or early April. RSV season in the southern hemisphere is discussed in related UpToDate content.

¶ RSV vaccination is administered as a one-time dose; repeat vaccination in subsequent pregnancies is not recommended due to lack of data.

Δ In many settings, nirsevimab is in limited supply.

◊ In most cases, infants born to mothers vaccinated with RSVPreF during pregnancy will not be offered nirsevimab after birth. Exceptions include infants with a high-risk condition and/or that were delivered <14 days after maternal vaccination.