NAS: neonatal abstinence syndrome; NOWS: neonatal opioid withdrawal syndrome.
* Nonpharmacologic measures should be provided for all substance-exposed neonates, regardless of whether they are demonstrating signs of withdrawal. Examples of nonpharmacologic measures include holding by the parent/caregiver, skin-to-skin contact, frequent small breast or bottle feeds, safe swaddling, non-nutritive sucking, and maintaining a quiet, low-stimulation environment.
¶ Huddles with parents/caregivers may occur in person, by video call, or over the phone. If the parents/caregivers leave the bedside, the clinical team should obtain a reliable contact number and make a plan for communication in the event that a huddle and/or pharmacologic treatment are needed while the parents/caregivers are off site. The purpose of the nurse/parent huddle is to formally review and reinforce nonpharmacologic measures that can be optimized to help the newborn with difficulties eating, sleeping, and consoling. The purpose of the full-team huddle is to consider all possible causes for the newborn's symptoms, to review and reinforce optimal use of nonpharmacologic measures, and to determine if pharmacologic treatment is needed.
Δ If the response is 'no' for every category, withdrawal symptoms are not significantly impairing the newborn's ability to eat, sleep, and console. Escalation of treatment is not necessary for these newborns.
◊ Morphine and methadone are the first-line pharmacologic agents for treatment of NAS/NOWS. Second-line adjunctive agents include clonidine and phenobarbital. Refer to UpToDate topics on NAS for guidance on dosing, titration, and weaning of these medications.