Lifileucel: Patient drug information
For additional information see "Lifileucel: Drug information"
You must carefully read the "Consumer Information Use and Disclaimer" below in order to understand and correctly use this information.
Warning
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Low blood cell counts have happened with this drug. Sometimes this lasted for weeks or longer after taking this drug. If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. Sometimes, very low blood cell counts have been deadly. If you have questions, talk with the doctor.
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Another drug like filgrastim may need to be used to help the bone marrow make blood cells during treatment with this drug. Follow what your doctor has told you to do.
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Have your blood work, heart function, and lung function checked as you have been told by your doctor.
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Call your doctor right away if you have any signs of infection like fever, chills, flu-like signs, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or a wound that will not heal.
What is this drug used for?
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It is used to treat a type of skin cancer (melanoma).
What do I need to tell my doctor BEFORE I take this drug?
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If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
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If you have an infection.
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If you are taking a steroid like prednisone.
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This is not a list of all drugs or health problems that interact with this drug.
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Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take this drug?
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Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
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You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
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You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
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If you have upset stomach, throwing up, diarrhea, or decreased appetite, talk with your doctor. There may be ways to lower these side effects.
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Kidney, heart, liver, and breathing problems have happened with this drug. Sometimes, these have been deadly. Closely read the part in this leaflet that lists when to call your doctor.
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If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting this drug. Talk with your doctor.
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Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.
What are some side effects that I need to call my doctor about right away?
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WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
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Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
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Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
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Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
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Signs of heart problems like chest pain; fast, slow, or abnormal heartbeat; or shortness of breath, a big weight gain, or swelling in the arms or legs.
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Signs of liver problems like dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
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Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
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Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
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Trouble breathing that is new or worse.
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Swelling.
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Feeling confused, not able to focus, or change in behavior.
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Feeling sleepy.
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Memory problems or loss.
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Infusion reactions have happened with this drug. Tell your doctor if you have fever, chills, fast heartbeat, rash, signs of low blood pressure like severe dizziness or passing out, shortness of breath, cough, chest tightness, wheezing, or any other bad effects during the infusion or within 1 day after getting this drug.
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Tell your doctor if you get signs of capillary leak syndrome (CLS) like change in the amount of urine passed; unable to pass urine; blood in the urine; a heartbeat that does not feel normal; chest pain or pressure; a fast heartbeat; shortness of breath; a big weight gain; throwing up blood or throw up that looks like coffee grounds; or if you have black, tarry, or bloody stools.
What are some other side effects of this drug?
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All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
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Feeling tired or weak.
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Diarrhea, upset stomach, or throwing up.
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Decreased appetite.
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Hair loss.
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Weight gain.
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Headache.
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These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
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You may report side effects to your national health agency.
How is this drug best taken?
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Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
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It is given as an infusion into a vein over a period of time.
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Other drugs may be given before this drug to help avoid side effects.
What do I do if I miss a dose?
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Call your doctor to find out what to do.
How do I store and/or throw out this drug?
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This drug will be given in a hospital or doctor's office. You will not store it at home.
General drug facts
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If your symptoms or health problems do not get better or if they become worse, call your doctor.
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Do not share your drugs with others and do not take anyone else's drugs.
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Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
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Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
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Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
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If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Last Reviewed Date2024-02-23
Consumer Information Use and Disclaimer
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This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patient's specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.
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