ILAR classification criteria for JIA in patients under 16 years

Subtype of JIA	Duration of symptoms	Inclusion criteria	Exclusion criteria
Systemic arthritis (systemic JIA)	≥2 weeks	Arthritis in ≥1 joint and fever (with at least 3 days of a quotidian pattern), plus ≥1 of the following features: Evanescent erythematous rash Generalized lymphadenopathy Hepatomegaly and/or splenomegaly Serositis	A personal history of or first-degree relative affected by psoriasis A personal history of or first-degree relative affected by certain conditions (including ERA, ankylosing spondylitis, sacroiliitis with IBD, reactive arthritis, and/or acute anterior uveitis) Arthritis starting after 6 years of age in a male patient who is positive for HLA-B27 Positive testing for RF^*
Oligoarticular arthritis (oligoarticular JIA)	≥6 weeks	Arthritis affecting 1 to 4 joints during the first 6 months of disease Considered persistent oligoarticular JIA if patients continue to have arthritis in 1 to 4 joints, versus extended oligoarticular JIA if patients go on to develop arthritis in ≥4 joints	A personal history of or first-degree relative affected by psoriasis A personal history of or first-degree relative affected by certain conditions (including ERA, ankylosing spondylitis, sacroiliitis with IBD, reactive arthritis, and/or acute anterior uveitis) Arthritis starting after 6 years of age in a male patient who is positive for HLA-B27 Positive testing for RF^* Features consistent with systemic JIA^¶
Polyarticular arthritis (polyarticular JIA)	≥6 weeks	Arthritis affecting ≥5 joints affected during the first 6 months of disease Further categorized as being positive or negative for RF^*	A personal history of or first-degree relative affected by psoriasis A personal history of or first-degree relative affected by certain conditions (including ERA, ankylosing spondylitis, sacroiliitis with IBD, reactive arthritis, and/or acute anterior uveitis) Arthritis starting after 6 years of age in a male patient who is positive for HLA-B27 Features consistent with systemic JIA^¶
Psoriatic arthritis (psoriatic JIA)	≥6 weeks	Simultaneous arthritis and psoriasis or arthritis plus ≥2 of the following: Dactylitis Nail pitting or onycholysis Psoriasis in a first-degree relative	A personal history of or first-degree relative affected by certain conditions (including ERA, ankylosing spondylitis, sacroiliitis with IBD, reactive arthritis, and/or acute anterior uveitis) Arthritis starting after 6 years of age in a male patient who is positive for HLA-B27 Positive testing for RF^* Features consistent with systemic JIA^¶
Enthesitis-related arthritis (ERA)	≥6 weeks	Arthritis and enthesitis, or arthritis or enthesitis plus ≥2 of the following: The presence of or history of sacroiliac joint tenderness and/or inflammatory back pain HLA-B27 positivity Onset of arthritis in a male over 6 years of age Acute anterior uveitis History in a first-degree relative of ankylosing spondylitis, ERA, sacroiliitis with IBD, reactive arthritis, or acute anterior uveitis	A personal history of or first-degree relative affected by psoriasis Positive testing for RF^* Features consistent with systemic JIA^¶
Undifferentiated arthritis	≥6 weeks	Patient does not meet the above criteria or if they fulfill criteria for 2 or more categories

To be used with UpToDate content on classification of JIA.

HLA: human leukocyte antigen; IBD: inflammatory bowel disease; ILAR: International League of Associations for Rheumatology; JIA: juvenile idiopathic arthritis; RF: rheumatoid factor.

* Positive testing for RF is defined as having a positive immunoglobulin M RF test on at least 2 occasions checked at least 3 months apart within the first 6 months of disease.

¶ Examples include fever, evanescent rash, and elevated ferritin.

Adapted from: Petty RE, Southwood TR, Manners P, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: Second revision, Edmonton, 2001. J Rheumatol 2004; 31:390.

Graphic 144459 Version 2.0

خرید پکیج

ILAR classification criteria for JIA in patients under 16 years