Overview of managing sexual dysfunction caused by selective serotonin reuptake inhibitors

SSRIs are first-line antidepressants for treating depressive disorders, which are widely prevalent; sexual dysfunction is one of the most common adverse effects of SSRIs. This algorithm provides an overview of treating SSRI-induced sexual dysfunction, including impairment of desire, arousal, and orgasm. Specific details are discussed in the UpToDate topic on managing sexual dysfunction caused by SSRIs.

SSRI: selective serotonin reuptake inhibitor.

* A reasonable alternative is switching to an antidepressant that causes less sexual dysfunction, such as bupropion, mirtazapine, or vortioxetine.

¶ Occasionally, an SSRI dose below the usual therapeutic range may be effective and ameliorate sexual dysfunction. A reasonable alternative to lowering the dose is switching to an antidepressant that causes less sexual dysfunction, such as bupropion, mirtazapine, or vortioxetine.

Δ Reasonable alternatives include nonpharmacologic interventions. Refer to the UpToDate topic on managing sexual dysfunction in females.

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Overview of managing sexual dysfunction caused by selective serotonin reuptake inhibitors