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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : -45 مورد

Preventing relapse of malaria due to P. vivax or P. ovale in breastfeeding mothers

Preventing relapse of malaria due to P. vivax or P. ovale in breastfeeding mothers
The life cycles of P. vivax and P. ovale include hypnozoites, which are dormant stages in the liver that can reactivate weeks, months, or years after initial infection, causing relapse. Therefore, following treatment of P. vivax or P. ovale infection, patients should receive treatment with primaquine to eradicate hypnozoite forms that may remain dormant in the liver.

G6PD: glucose-6-phosphate-dehydrogenase.

* Primaquine can cause hemolytic anemia in individuals with G6PD deficiency. This drug is contraindicated while breastfeeding for mothers whose infants are G6PD deficient or whose infant G6PD status is unknown. In such cases, breastfeeding mothers should be treated with chloroquine prophylaxis (in areas with chloroquine-sensitive infection) until cessation of breastfeeding; thereafter, they should receive antirelapse therapy as nonpregnant, nonlactating patients.

¶ Refer to the UpToDate topic on treatment of malaria due to P. vivax or P. ovale for approach to relapse prevention in nonpregnant, nonlactating patients.

Δ The mother and infant should have close monitoring for signs of hemolysis.

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