Tovorafenib: Patient drug information

What is this drug used for?

It is used to treat a type of brain tumor.

What do I need to tell my doctor BEFORE I take this drug?

If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
If you are breast-feeding. Do not breast-feed while you take this drug and for 2 weeks after your last dose.
This drug may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

For all patients taking this drug:
Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
Have your blood work and other lab tests checked as you have been told by your doctor.
You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
If you have constipation, diarrhea, throwing up, or upset stomach, talk with your doctor. There may be ways to lower these side effects.
Low white and red blood cell counts have happened with this drug. If white blood cell counts get low, the chance of getting an infection may be raised. If red blood cell counts get low, this can lead to anemia and a blood transfusion. If you have questions, talk with the doctor.
This drug may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. If you plan to get pregnant or father a child, talk with your doctor before taking this drug.
This drug may cause harm to an unborn baby. A pregnancy test will be done before you start this drug to show that you are NOT pregnant.
If you or your sex partner may become pregnant, you must use birth control while taking this drug and for some time after the last dose. Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy while taking this drug. Talk with your doctor about what type of birth control to use and how long to use it. If you or your sex partner gets pregnant, call your doctor right away.
Children:
If your child's weight changes, talk with the doctor. The dose of this drug may need to be changed.
This drug may affect growth in children and teens in some cases. They may need regular growth checks. Talk with the doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
Signs of liver problems like dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
Signs of electrolyte problems like mood changes; confusion; muscle pain, cramps, or spasms; weakness; shakiness; change in balance; an abnormal heartbeat; seizures; loss of appetite; or severe upset stomach or throwing up.
Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
Dizziness.
Swelling.
Fever, chills, or sore throat.
Skin reactions are common with this drug. Sometimes skin reactions can be severe. Call your doctor right away if you have any new or worse skin reactions. This includes a rash, bumps, acne, peeling, redness, or blisters.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
Constipation, diarrhea, stomach pain, upset stomach, or throwing up.
Change in color of hair.
Dry skin.
Itching.
Feeling tired or weak.
Signs of a common cold.
Change in nails.
Mouth irritation or mouth sores.
Headache.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
All products:
Take with or without food.
This drug is only taken once a week.
If you throw up right after taking a dose, take the dose again. If you are not sure if you need to take a dose again, talk with your doctor.
Keep taking this drug as you have been told by your doctor or other health care provider, even if you feel well.
Tablets:
Swallow whole with a full glass of water.
Do not chew, break, or crush.
Powder for suspension:
Do not use if the bottle is broken or damaged.
This drug comes with an adapter and oral dosing syringes. Use the adapter and syringe to add 14 mL of room temperature water to the bottle. Put the cap back on and shake well. Be sure you know how to mix after adding the water. If you have any questions, read the package insert or talk with the doctor or pharmacist.
Do not shake for longer than 2 minutes. If you still see powder after 2 minutes, call the doctor or pharmacist.
After mixing, measure doses carefully. Use the dosing syringe that comes with this drug. Each syringe is for one use only. Throw syringe away after use.
Take your dose within 15 minutes after mixing. Throw away any part not used within 15 minutes of mixing.
Sit upright to take a dose. Place the tip of the syringe into the mouth on the inside of your cheek. Gently push the plunger until all the drug is gone. Do not squirt quickly. This could cause choking.
Each bottle is for one use only. Throw away the opened bottle and any part of prepared suspension not used after the dose is given.
Those who have certain feeding tubes may use this drug. This drug is not for use with some feeding tubes. Talk with the doctor. Use as you have been told. Flush the feeding tube after this drug is given.

What do I do if I miss a dose?

Take a missed dose as soon as you think about it. After taking a missed dose, take your next dose on your normal day.
If you miss your dose by more than 3 days, skip the missed dose. Take your next dose on your normal day.
If you are not sure what to do if you miss a dose, call your doctor.

How do I store and/or throw out this drug?

All products:
Store at room temperature in a dry place. Do not store in a bathroom.
Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Tablets:
Do not take this drug out of the blister pack until you are ready to take it. Take this drug right away after opening the blister pack. Do not store the removed drug for future use.

General drug facts

If your symptoms or health problems do not get better or if they become worse, call your doctor.
Do not share your drugs with others and do not take anyone else's drugs.
Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patient's specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

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Tovorafenib: Patient drug information