Data from a series of 366 monochorionic twin pregnancies prenatally diagnosed with stage 1 to 4 TAPS and managed in 17 fetal therapy centers

	Expectant management (%)	Laser ablation (%)	Fetal transfusion (%)	Selective feticide (%)	Delivery (%)
Perinatal mortality	17	18	18	7	10
Severe neonatal morbidity^*	31	31	46	25	49
Stage 1 or 2 at diagnosis	86	69	79	57	83
Stage 3 or 4 at diagnosis	14	31	21	43	17
Median gestational age at intervention (weeks)		22	26	22	32
Diagnosis to birth interval (weeks)	7.8	9.7	4.0	10.5	0.3

These data reflect the initial management strategy after diagnosis. The subsequent management of the expectant management, laser, and transfusion groups varied.

IVH: intraventricular hemorrhage; TAPS: twin anemia-polycythemia sequence.

* Defined as at least one of the following within 28 days after birth or before discharge to home: respiratory distress syndrome requiring mechanical ventilation and surfactant, patent ductus arteriosus requiring treatment, necrotizing enterocolitis ≥stage 2, retinopathy of prematurity ≥stage 3, amniotic band sequence, ischemic limb injury, or severe cerebral injury (IVH ≥stage 3, ventricular dilation, cystic periventricular leukomalacia ≥grade 2, porencephalic or parenchymal cy

Adapted from: Tollenaar LSA, Slaghekke F, Lewi L, et al. Treatment and outcome of 370 cases with spontaneous or post-laser twin anemia-polycythemia sequence managed in 17 fetal therapy centers. Ultrasound Obstet Gynecol 2020; 56:378.

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خرید پکیج

Data from a series of 366 monochorionic twin pregnancies prenatally diagnosed with stage 1 to 4 TAPS and managed in 17 fetal therapy centers