(A, B) MRI from patient 7, obtained on day 30 after symptom onset, shows extensive, confluent fluid-attenuated inversion recovery (FLAIR) abnormalities involving the left occipital lobe and the frontal and temporal regions, bilaterally, with moderate diffusion restriction (not shown).
(C) MRI from patient 14, obtained on day 45 after symptom onset, shows extensive multiple cortical-subcortical FLAIR abnormalities involving bilateral frontal, temporal, and parietal-occipital lobes, without diffusion restriction, but mild gyriform leptomeningeal enhancement in the right temporal pole (not shown). Biopsy was performed in the right frontal region.
(D) Follow-up MRI obtained 2.5 months later (4 months after symptom onset) shows substantial improvement and resolution of most abnormalities.