Version July 2025
| Antibiotic | Dose (oral) |
| Amoxicillin-clavulanate | 250 to 500 mg twice daily (dose is based on amoxicillin component) |
| Cephalexin | 250 to 500 mg twice daily |
| Ciprofloxacin* | 500 to 750 mg once daily |
| Clarithromycin | 500 mg loading dose, then 250 mg twice daily |
| Clindamycin | 300 mg 4 times per day or 450 mg 3 times per day |
| Cloxacillin¶ | 500 mg 4 times per day |
| Dicloxacillin | 500 mg 4 times per day |
| Erythromycin | 500 mg 4 times per day |
| Flucloxacillin¶ | 500 mg 4 times per day |
| FluconazoleΔ | 200 mg every other day or 100 mg once daily |
| Isoniazid | 200 to 300 mg once daily |
| Linezolid | 600 mg twice daily for 48 hours, then 300 mg twice daily |
| Levofloxacin* | 250 mg once daily or 500 mg every other day |
| Metronidazole | 500 mg 3 times per day |
| Moxifloxacin | 400 mg once daily |
| NystatinΔ | 500,000 units 4 times per day |
| Ofloxacin | 400 mg on day 1, then 200 mg once daily |
| Rifampin (rifampicin)◊ | Patients weighing <50 kg: 450 mg once daily Patients weighing ≥50 kg: 600 mg once daily |
| Trimethoprim-sulfamethoxazole (co-trimoxazole) | 80 mg/400 mg (one single-strength tablet) once or twice daily or 160 mg/800 mg (one double-strength tablet) once daily |
* Slowly resolving or recurrent Pseudomonas exit-site infections should be treated with a second antipseudomonal drug. Refer to UpToDate content on peritoneal catheter exit-site and tunnel infections in peritoneal dialysis.
¶ Not available in the United States.
Δ Fluconazole and nystatin dosing in this table is for antifungal prophylaxis during antibiotic therapy. For details, refer to UpToDate content for peritoneal catheter exit-site and tunnel infections in peritoneal dialysis.
◊ Rifampin (rifampicin) is reserved for combination treatment with another anti-staphylococcal agent for slowly resolving Staphylococcus aureus exit-site infections. Due to rapid emergence of resistance, rifampin is not appropriate for use as a single agent. For details, refer to UpToDate content for peritoneal catheter exit-site and tunnel infections in peritoneal dialysis.Adapted from: Li PK, Szeto CC, Piraino B, et al. Peritoneal Dialysis-Related Infections Recommendations: 2010 Update. Perit Dial Int 2010; 30:393.
With additional data from: Chow KM, Li PK, Cho Y, et al. ISPD Catheter-related Infection Recommendations: 2023 Update. Perit Dial Int 2023; 43:201.