Correlation between tumor mutational burden and objective response rate with anti-PD-1 or anti-PD-L1 therapy in 27 tumor types

Shown is the median number of coding somatic mutations per MB of DNA in 27 tumor types or subtypes among patients who received inhibitors of PD-1 protein or its ligand (PD-L1), as described in published studies for which data regarding the ORR are available. The number of patients who were evaluated for the ORR is shown for each tumor type (size of the circle), along with the number of tumor samples that were analyzed to calculate the TMB (degree of shading of the circle). Data on the x axis are shown on a logarithmic scale.