ACT: activated clotting time; aPTT: activated partial thromboplastin time; CBC: complete blood count; DIC: disseminated intravascular coagulation; EXTEM CT: clot time using thromboelastometry; FFP: fresh frozen plasma; FIBTEM A10: clot strength measured as the point of displacement 10 min after initial clot formation using thromboelastometry; Hb: hemoglobin; INR: international normalized ratio; IU: international units; MA: amplitude measured at peak clot strength using thromboelastography; PCC: prothrombin complex concentrate; PT: prothrombin time; RBCs: red blood cells; r-TEG: rapid thromboelastography; VET: viscoelastic testing.
* Refer to UpToDate content on management of intraoperative bleeding.
¶ Refer to UpToDate content on point-of-care hemostasis testing (viscoelastic tests).
Δ Higher fibrinogen targets may be needed in some individuals, especially in patients who are pregnant, or if fibrinogen levels are dropping or bleeding persists despite other measures.
◊ Either 3-factor or 4-factor PCC.