Version July 2025
| More commonly implicated |
| Neuromuscular blocking agents (succinylcholine, rocuronium, atracurium, cisatracurium, vecuronium, pancuronium, mivacurium) |
| Antibiotics (eg, penicillins, cephalosporins, vancomycin; many others less frequently) |
| Chlorhexidine |
| Blue dyes (isosulfan blue, patent blue V, methylene blue) |
| Latex |
| Less commonly implicated |
| Animal-derived medications and products (due to alpha-gal) |
| Gelatin (eg, in surgical sponges, bovine thrombin hemostatic agents, colloids) |
| Propofol |
| Sugammadex |
| Least commonly implicated |
| Aprotinin (intravenous or in biologic sealants) |
| Bacitracin |
| Barbiturates (methohexital, thiopental [not used in the United States]) |
| Benzodiazepines |
| Blood products |
| Chymopapain and papain |
| Colloids |
| Ethylene oxide |
| Heparin |
| Hyaluronidase |
| Insulin |
| Local anesthetics |
| Metabisulfites and bisulfites used as preservatives in medications |
| Nonbarbiturates other than propofol (etomidate, ketamine) |
| Nonsteroidal antiinflammatory drugs (NSAIDs) |
| Opioids |
| Ortho-phthalaldehyde (Cidex OPA [brand name]) |
| Povidone |
| Protamine |
| Radiocontrast agents |
| Streptokinase or urokinase |
