| | Factors that put someone at highest risk for acquiring HIV | Other factors associated with acquiring HIV |
| Anal sex (insertive or receptive), particularly male same-sex intercourse | - Condomless sex with partner with HIV and viral load is >200 copies/mL or unknown
- Condomless sex with multiple or anonymous sex partners
- Condomless sex with a partner at high risk for HIV (eg, from high prevalence setting, uses injection drugs)
- Has been diagnosed with an STI (eg, syphilis, gonorrhea, chlamydia, mpox)
| - All other condomless anal sex, except if in mutually monogamous relationships with a partner known to be HIV negative or to have HIV viral load <200 copies/mL
|
| Vaginal sex (insertive or receptive) | - Condomless sex with a partner with HIV and the viral load is >200 copies/mL or unknown
- Condomless sex with partner(s) at high risk for HIV (eg, multiple/anonymous partners from regions with high prevalence of HIV, main partner who uses injection drugs)
- Has been diagnosed with syphilis, gonorrhea, mpox
| - Multiple partners from regions with low HIV prevalence
- Has been diagnosed with other STI (eg, chlamydia, trichomonas)
|
