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خرید پکیج
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Alcohol consumption and risk of liver disease

Alcohol consumption and risk of liver disease
Females Males
NIAAA[1]
  • Heavy drinking : >112 g per week
  • Heavy drinking: >210 g per week
NIAAA Alcoholic Hepatitis Consortia[2]
  • At risk for alcohol-associated hepatitis: >280 g per week
  • At risk for alcohol-associated hepatitis: >420 g per week
WHO[3]
  • Low risk: 0 to 140 g per week
  • Medium risk: 140 to 280 g per week
  • High risk: 280 to 420 g per week
  • Very high risk: >420 g per week
  • Low risk: 0 to 280 g per week
  • Medium risk: 280 to 420 g per week
  • High risk: 420 to 700 g per week
  • Very high risk: >700 g per week
Multisociety consensus statement for MASLD*[4]
  • MASLD: <140 g per week
  • MetALD: 140 to 350 g per week
  • ALD: >350 g per week
  • MASLD: <210 g per week
  • MetALD: 210 to 420 g per week
  • ALD: >420 g per week
The level of alcohol consumption that increases risk of developing liver and other diseases has been defined by several expert groups and professional organizations. Amounts are based on one standard drink, which is defined as 14 grams of ethanol, as found in 12 oz (360 mL) of beer, 5 oz (150 mL) of wine, or 1.5 oz (45 mL) of 80-proof spirits.

ALD: alcohol-associated liver disease; MASLD: metabolic dysfunction-associated steatotic liver disease; MetALD: metabolic dysfunction- and alcohol-associated liver disease; NIAAA: National Institute on Alcohol Abuse and Alcoholism; WHO: World Health Organization.

* Steatotic liver disease is classified by the presence of risk factors for cardiometabolic dysfunction (eg, dyslipidemia) and by alcohol consumption. For details, refer to UpToDate content on MASLD.

References:
  1. What is alcohol misuse? National Institute on Alcohol Abuse and Alcoholism. https://rethinkingdrinking.niaaa.nih.gov/how-much-too-much/what-alcohol-misuse (Accessed on April 23, 2025).
  2. Crabb DW, Bataller R, Chalasani NP, et al. Standard definitions and common data elements for clinical trials in patients with alcoholic hepatitis: Recommendation from the NIAAA Alcoholic Hepatitis Consortia. Gastroenterology 2016; 150:785.
  3. Alcohol. World Health Organization. https://www.who.int/health-topics/alcohol (Accessed on April 23, 205).
  4. Rinella ME, Lazarus JV, Ratziu V, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology 2023; 78:1966.
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