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Peptic ulcer disease: Treatment and secondary prevention

Peptic ulcer disease: Treatment and secondary prevention
Author:
Nimish B Vakil, MD, AGAF, FACP, FACG, FASGE
Section Editor:
Mark Feldman, MD, MACP, AGAF, FACG
Deputy Editor:
Shilpa Grover, MD, MPH, AGAF
Literature review current through: Jan 2023. | This topic last updated: Aug 08, 2022.

INTRODUCTION — A peptic ulcer is a defect in the gastric or duodenal wall that extends through the muscularis mucosa into the deeper layers of the wall. The management of patients with peptic ulcer disease is based on the etiology, ulcer characteristics, and anticipated natural history. This topic will review the initial management of peptic ulcer disease. The management of recurrent peptic ulcer disease, the complications of peptic ulcer disease, surgical management of peptic ulcer disease, and the clinical manifestations and diagnosis of peptic ulcer disease are discussed separately. (See "Approach to refractory peptic ulcer disease" and "Overview of complications of peptic ulcer disease" and "Surgical management of peptic ulcer disease" and "Peptic ulcer disease: Clinical manifestations and diagnosis".)

INITIAL MANAGEMENT

Treat the underlying etiology

Eradication of Helicobacter pylori (H. pylori) — Patients with peptic ulcers should be tested for infection with H. pylori and treated accordingly (algorithm 1) [1-4]. Eradication of H. pylori in patients with peptic ulcer disease is associated with higher healing rates in patients with duodenal and gastric ulcers. A meta-analysis of 24 randomized trials that included 2102 patients with peptic ulcer disease revealed that the 12-month ulcer remission rates for gastric and duodenal ulcers were significantly higher in patients successfully eradicated of H. pylori infection as compared with those with a persistent infection (97 and 98 percent versus 61 and 65 percent, respectively) [5]. In addition, eradication of H. pylori infection is associated with lower ulcer recurrence rates in patients with gastric and duodenal ulcers who are not placed on maintenance antisecretory therapy [6]. Treatment regimens for H. pylori are discussed in detail, separately. (See "Indications and diagnostic tests for Helicobacter pylori infection in adults" and "Treatment regimens for Helicobacter pylori in adults".)

Discontinue nonsteroidal anti-inflammatory drugs (NSAIDs) — Patients with peptic ulcers should be advised to avoid NSAIDs. NSAIDs, including aspirin, increase the risk of peptic ulcer disease and are associated with an increased risk of complications from a peptic ulcer.

Rare or unclear cause — Rare causes of ulcer disease (eg, infections, Crohn disease, ischemia) should be addressed and treated. In patients with peptic ulcer disease of unclear etiology, additional evaluation is needed to exclude other rare causes of peptic ulcer disease (see "Unusual causes of peptic ulcer disease"). Gastrointestinal bleeding is a complication of severe coronavirus infections and peptic ulcer disease is the most common cause. In one study of consecutive patients in Northern Italy, the prevalence was 0.5 percent and the mortality rate was 21 percent, primarily due to pulmonary complications [7].

Initial antisecretory therapy

Choice of therapy — All patients with peptic ulcers should receive antisecretory therapy with a proton pump inhibitor (PPI) (eg, omeprazole 20 to 40 mg daily or equivalent) to facilitate ulcer healing (algorithm 1 and table 1). PPI use results in faster control of peptic ulcer disease symptoms and higher ulcer healing rates as compared with H2RA as a consequence of stronger acid suppression. PPIs also heal NSAID-related ulcers more effectively as compared with H2RAs [8]. (See "Antiulcer medications: Mechanism of action, pharmacology, and side effects", section on 'Indications and comparative efficacy' and "Proton pump inhibitors: Overview of use and adverse effects in the treatment of acid related disorders", section on 'Pharmacology'.)

Combining PPIs and H2RAs adds to cost without enhancing healing. Although antacids and sucralfate can heal duodenal ulcers, they are not routinely recommended to treat peptic ulcers as PPIs heal ulcers more rapidly and to a greater extent.

Duration — The duration of initial antisecretory therapy varies based on the ulcer characteristics, the underlying etiology (H. pylori, NSAID use) and the presence of ulcer complications (eg, bleeding, perforation, penetration, or gastric outlet obstruction) [9]. (See "Overview of complications of peptic ulcer disease" and 'Prevention of recurrence' below.)

Complicated ulcer — All patients with complicated peptic ulcers (ulcers with bleeding, perforation, penetration, or gastric outlet obstruction) should initially receive high-dose acid suppressive therapy. The treatment of bleeding peptic ulcers is discussed in detail separately. (See "Approach to acute upper gastrointestinal bleeding in adults", section on 'Acid suppression'.)

In patients with peptic-ulcer-related complications other than bleeding (gastric outlet obstruction, penetration, perforation), high-dose twice-daily PPI treatment is reasonable to enhance healing (eg, oral omeprazole 40 mg twice daily), but dosing should generally be reduced to once daily after four weeks. In patients with complicated duodenal ulcers, we suggest antisecretory treatment for four to eight weeks. In patients with complicated gastric ulcers, we suggest antisecretory therapy for a total duration of 8 to 12 weeks. In patients with gastric ulcers, we discontinue antisecretory therapy only after ulcer healing has been confirmed by upper endoscopy. (See "Overview of complications of peptic ulcer disease", section on 'Acid suppressive therapy' and 'Gastric ulcers' below.)

Uncomplicated ulcer

H. pylori-positive ulcer — In patients with uncomplicated ulcers, PPI (eg, omeprazole 20 mg twice daily) given for 14 days, along with the antibiotic regimen to treat H. pylori, is usually adequate to induce healing. Additional antisecretory therapy is not needed in the absence of persistent or recurrent symptoms following therapy or other indications for maintenance antisecretory therapy [10,11]. Eradication of H. pylori even without concurrent acid suppression therapy heals >90 percent of duodenal ulcers [12,13]. (See 'Prevention of recurrence' below.)

NSAID-induced ulcer — Patients with NSAID-associated ulcers should be treated with a PPI (eg, omeprazole 20 to 40 mg daily) for four to eight to weeks based on the size of the ulcer (table 1). In patients with peptic ulcers who need to remain on NSAIDs or aspirin, maintenance antisecretory therapy with a PPI (eg, omeprazole 20 mg daily) can reduce the risk of ulcer complications or recurrence [14]. (See "NSAIDs (including aspirin): Secondary prevention of gastroduodenal toxicity", section on 'Secondary prevention of gastroduodenal toxicity' and 'Prevention of recurrence' below.)

Non-H. pylori, non-NSAID ulcer — In patients with H. pylori-negative ulcers that are not associated with NSAID use, we suggest initial PPI therapy for four weeks for uncomplicated duodenal ulcers, and eight weeks for a gastric ulcer or any complicated ulcer before repeat endoscopic evaluation to assess for ulcer healing. Although the natural history of these ulcers is unclear, it is important to review the patient's history for the adequacy of H. pylori testing and for a history of NSAID use. Limited data on the natural history of these ulcers suggest that they may be more difficult to heal and have a higher rate of recurrence. In the absence of H. pylori and NSAID use, we continue long-term acid inhibitory therapy with PPIs [15]. (See 'Prevention of recurrence' below and 'Repeat upper endoscopy in selected patients' below.)

Other general measures — Underlying risk factors for peptic ulcer disease should be addressed and treated. Given the many benefits of smoking cessation, we advise patients to stop smoking and advise them to limit alcohol intake to one alcoholic beverage a day [16]. Evidence to support the use of a bland diet or dietary restrictions in patients with peptic ulcer disease is lacking. (See "Peptic ulcer disease: Epidemiology, etiology, and pathogenesis", section on 'Risk factors'.)

SUBSEQUENT MANAGEMENT

Repeat upper endoscopy in selected patients

Duodenal ulcers — Given the low risk of malignancy in patients with duodenal ulcers, a repeat upper endoscopy is not routinely recommended, but may be performed in selected patients four weeks after initial treatment unless symptoms persist or recur (algorithm 1). Endoscopy should be repeated in patients with signs of ongoing bleeding [17]. The decision to perform a repeat upper endoscopy in patients with duodenal ulcers of unclear etiology should be individualized. (See "Unusual causes of peptic ulcer disease".)

Gastric ulcers — We suggest a surveillance endoscopy (with biopsies of the ulcer if still present) be performed after 8 to 12 weeks in patients with gastric ulcers and any one of the following (algorithm 1):

●Symptoms persist despite medical therapy.

●Unclear etiology.

●Giant ulcer (>2 cm).

●Biopsies not performed or inadequate sampling on the index upper endoscopy. To adequately sample a gastric ulcer, we suggest a minimum of four biopsies should be obtained, with at least one from each of the four quadrants of the ulcer. Additional biopsies of the edges should be taken with jumbo forceps if there are endoscopic features of a malignant gastric ulcer.

●Ulcer appears suspicious for malignancy on index upper endoscopy (mass lesion, elevated irregular ulcer borders, or abnormal adjacent mucosal folds). Surveillance endoscopy should be considered in patients whose gastric ulcer appears endoscopically suspicious for malignancy, even if biopsy samples from the index endoscopy are benign. False-negative biopsy specimen results have been reported to occur in 2 percent to 5 percent of malignant ulcers.

●Patients with bleeding ulcers at initial presentation who show signs of continued bleeding [17].

●Risks factors for gastric cancer (eg, age >50 years, Helicobacter pylori, immigrants from a region with high prevalence of gastric cancer [eg, Japan, Korea, Taiwan, Costa Rica], family history of gastric cancer, the presence of gastric atrophy, adenoma, dysplasia, intestinal metaplasia).

Our approach is not to perform an upper endoscopy for surveillance in patients with small benign-appearing antral gastric ulcers due to nonsteroidal anti-inflammatory drug use that have been adequately biopsied and have no evidence of dysplasia or malignancy if the patient has no risk factors for gastric cancer [18-20].

There are limited prospective outcome data to guide which patients with peptic ulcers should undergo surveillance endoscopy. Our recommendations are consistent with the 2010 guidelines by the American Society for Gastrointestinal Endoscopy [17]. The incidence of gastric cancer on follow-up endoscopy of an apparently benign gastric ulcer ranges from 0.8 to 4.3 percent. The rationale behind endoscopic follow-up of a patient with a gastric ulcer is that the absence of symptoms does not reliably exclude malignancy, and surveillance endoscopy may identify patients with gastric cancer at an early stage [21,22]. However, it is unclear if endoscopic surveillance is cost-effective or improves survival [21,23].

Refractory ulcers — A refractory peptic ulcer is defined as an endoscopically proven ulcer greater than 5 mm in diameter that does not heal after 8 to 12 weeks of treatment with a proton pump inhibitor (PPI). Approximately 5 to 10 percent of ulcers are refractory to initial PPI therapy. The evaluation and management of refractory ulcers is discussed elsewhere. (See "Approach to refractory peptic ulcer disease".)

PREVENTION OF RECURRENCE

Aspirin/nonsteroidal anti-inflammatory drug (NSAID) avoidance — The need for aspirin and NSAIDs should be carefully assessed in patients with a history of peptic ulcer disease. NSAIDs, including aspirin, increase the risk of bleeding in patients with prior peptic ulcer disease. For patients who must continue aspirin or NSAIDs, or both, we recommend treatment with a proton pump inhibitor (PPI) for as long as the NSAID and/or aspirin is used. This is particularly important in patients who need continued NSAIDs and have additional risk factors for gastroduodenal toxicity (age >65 years, complicated peptic ulcer disease, high-dose NSAID use, NSAID use with other medications associated with peptic ulcer disease [eg, SSRIs, low-dose aspirin]). (See "NSAIDs (including aspirin): Secondary prevention of gastroduodenal toxicity".)

H. pylori eradication — In addition, H. pylori infection should be eradicated, if known to be present. For patients with H. pylori infection who cannot discontinue NSAIDs, rebleeding rates are reduced with eradication of H. pylori infection in combination with long-term PPI therapy. (See "Indications and diagnostic tests for Helicobacter pylori infection in adults", section on 'Confirmation of eradication'.)

In patients treated for H. pylori, eradication of infection should be confirmed four or more weeks after the completion of therapy [4]. The choice of test depends on the need for an upper endoscopy (eg, follow-up of bleeding peptic ulcer). (See 'Repeat upper endoscopy in selected patients' above and "Indications and diagnostic tests for Helicobacter pylori infection in adults".)

PPIs should be held for one to two weeks prior to testing to reduce false-negative results. Serologic testing should not be performed to confirm eradication as patients may continue to have antibodies after eradication. Diagnostic evaluation and treatment of H. pylori are discussed in detail, separately. (See "Indications and diagnostic tests for Helicobacter pylori infection in adults", section on 'Medications that should be discontinued prior to testing'.)

Maintenance antisecretory therapy — The decision to continue maintenance antisecretory therapy varies based on the patient and ulcer characteristics and risk factors for recurrent peptic ulcer disease [9]. While PPIs, H2 receptor antagonists, and prostaglandin analogs have been used as maintenance therapy to prevent recurrent ulcers, PPIs are the most effective agents in preventing recurrent ulcers and recurrent ulcer bleeding [24].

We continue maintenance antisecretory therapy with a PPI (eg, omeprazole 20 mg daily) in the following patients with peptic ulcer disease (table 1) [25-31]:

●Giant (>2 cm) peptic ulcer and age >50 years or multiple co-morbidities

●H. pylori-negative, NSAID-negative ulcer disease

●Failure to eradicate H. pylori (including salvage therapy)

●Frequently recurrent peptic ulcers (>2 documented recurrences a year)

●Continued NSAID use

The prevention of recurrent gastroduodenal toxicity associated with NSAID, low-dose aspirin or both therapies (secondary prevention) is discussed in detail, separately. (See "NSAIDs (including aspirin): Secondary prevention of gastroduodenal toxicity" and "Overview of the treatment of bleeding peptic ulcers", section on 'Resumption of anticoagulants and antiplatelet agents'.)

TREATMENT DURING PREGNANCY AND LACTATION — When peptic ulcer disease is diagnosed in a woman who is pregnant, the focus of treatment is typically acid suppression with a proton pump inhibitor (PPI) [32]. If Helicobacter pylori (H. pylori) is present, antimicrobial treatment is typically deferred until after delivery. However, there is some evidence that H. pylori can cause severe nausea/vomiting in pregnancy, including hyperemesis gravidarum [33,34]. Thus, if indicated, H. pylori treatment can be considered in pregnancy. A meta-analysis of safety studies showed no significant adverse outcomes with PPI use in pregnant women [35-37]. The available evidence based on clinical studies in pregnancy supports the safety of older proton pump inhibitors such as omeprazole and pantoprazole with little data available on the newer proton pump inhibitors. Similarly, limited data with omeprazole and pantoprazole suggest that excretion in breast milk does occur but the levels are low [38-40]. (See "Medical management of gastroesophageal reflux disease in adults", section on 'Pregnancy and lactation' and "Prenatal care: Patient education, health promotion, and safety of commonly used drugs", section on 'Antibiotics'.)

DISEASE COURSE — Approximately 60 percent of peptic ulcers heal spontaneously but with eradication of Helicobacter pylori (H. pylori) infection, ulcer healing rates are >90 percent [5,41-44]. Approximately 5 to 10 percent of ulcers are refractory to antisecretory therapy with a proton pump inhibitor (PPI). The risk of complications in patients with chronic peptic ulcer disease is 2 to 3 percent per year. (See "Approach to refractory peptic ulcer disease".)

Even with continued PPI use, approximately 5 to 30 percent of peptic ulcers recur within the first year based on whether H. pylori has been successfully eradicated [45,46]. Recurrent ulcers are usually due to H. pylori infection or nonsteroidal anti-inflammatory drug use but in rare cases may be due to other etiologies (table 2).

SOCIETY GUIDELINE LINKS — Links to society and government-sponsored guidelines from selected countries and regions around the world are provided separately. (See "Society guideline links: Peptic ulcer disease".)

INFORMATION FOR PATIENTS — UpToDate offers two types of patient education materials, "The Basics" and "Beyond the Basics." The Basics patient education pieces are written in plain language, at the 5th to 6th grade reading level, and they answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials. Beyond the Basics patient education pieces are longer, more sophisticated, and more detailed. These articles are written at the 10th to 12th grade reading level and are best for patients who want in-depth information and are comfortable with some medical jargon.

Here are the patient education articles that are relevant to this topic. We encourage you to print or e-mail these topics to your patients. (You can also locate patient education articles on a variety of subjects by searching on "patient info" and the keyword(s) of interest.)

●Basics topics (see "Patient education: Peptic ulcers (The Basics)" and "Patient education: H. pylori infection (The Basics)" and "Patient education: Gastritis (The Basics)")

●Beyond the Basics topics (see "Patient education: Peptic ulcer disease (Beyond the Basics)" and "Patient education: Helicobacter pylori infection and treatment (Beyond the Basics)")

SUMMARY AND RECOMMENDATIONS

●Treatment of the underlying etiology

•Patients with peptic ulcer disease should be tested for Helicobacter pylori (H. pylori). Patients with H. pylori should be treated with a goal of eradication of H. pylori infection. In patients treated for H. pylori, eradication of infection should be confirmed four or more weeks after the completion of eradication therapy. (See "Indications and diagnostic tests for Helicobacter pylori infection in adults".)

•Patients with peptic ulcers should be advised to avoid nonsteroidal anti-inflammatory drugs (NSAIDs). Contributing factors should be addressed and treated (eg, treating medical comorbidities, poor nutritional status, ischemia). (See 'Rare or unclear cause' above and "Unusual causes of peptic ulcer disease", section on 'Etiology' and "Unusual causes of peptic ulcer disease", section on 'Evaluation of H. pylori and NSAID negative ulcers'.)

●Antisecretory therapy – All patients with peptic ulcer disease should receive antisecretory therapy with a proton pump inhibitor (PPI) to facilitate ulcer healing (algorithm 1). The choice and duration of therapy varies based on the etiology, ulcer location (eg, gastric or duodenal), and the presence of ulcer complications (eg, bleeding, perforation, penetration, or gastric outlet obstruction). (See 'Initial antisecretory therapy' above.)

●Indications for surveillance endoscopy

•Patients with duodenal ulcers who have been treated do not need further endoscopy unless symptoms persist at four weeks or recur. (See 'Duodenal ulcers' above.)

•In patients with gastric ulcers, the decision to perform surveillance endoscopy should be individualized. We suggest surveillance endoscopy (with biopsies of the ulcer if still present) be performed after 8 to 12 weeks of antisecretory therapy in patients with gastric ulcers and any one of the following (see 'Repeat upper endoscopy in selected patients' above):

-Symptoms despite medical therapy

-Unclear etiology

-Giant gastric ulcer (>2 cm)

-Biopsies not performed or inadequate sampling on the index upper endoscopy

-Ulcer appears suspicious for malignancy on index upper endoscopy (mass lesion, elevated irregular ulcer borders, or abnormal adjacent mucosal folds)

-Patients with bleeding ulcers at initial presentation who show signs of continued bleeding

-Risks factors for gastric cancer

●Prevention of recurrence

•The need for aspirin and NSAIDs should be carefully assessed in patients with a history of peptic ulcer disease. NSAIDs, including aspirin, increase the risk of bleeding in patients with prior peptic ulcer disease. In patients treated for H. pylori, eradication of infection should be confirmed four or more weeks after the completion of therapy.

•Maintenance antisecretory therapy should be limited to high-risk subgroups of patients with peptic ulcer disease. These include individuals with any one of the following (see 'Prevention of recurrence' above):

-Refractory peptic ulcer

-H. pylori-negative, NSAID-negative ulcer disease

-Giant (>2 cm) ulcer and age >50 years or multiple comorbidities

-Failure of H. pylori eradication, including rescue therapies

-Frequently recurrent peptic ulcers (>2 documented recurrences a year)

-Continued NSAID use

●Disease course – Approximately 60 percent of peptic ulcers heal spontaneously but with eradication of H. pylori infection, ulcer healing rates are >90 percent. Even with continued proton pump inhibitor (PPI) use, approximately 5 to 30 percent of peptic ulcers recur within the first year based on whether H. pylori has been successfully eradicated. Approximately 5 to 10 percent of ulcers are refractory to antisecretory therapy with a PPI. The risk of complications in patients with chronic peptic ulcer disease is 2 to 3 percent per year. (See 'Disease course' above and "Approach to refractory peptic ulcer disease" and "Overview of complications of peptic ulcer disease".)

ACKNOWLEDGMENT — The UpToDate editorial staff acknowledges Andrew H. Soll, MD, who contributed to an earlier version of this topic review.

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Topic 25 Version 32.0

References

1 : NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease.

2 : Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori.

3 : Changing rates of Helicobacter pylori testing and treatment in patients with peptic ulcer disease.

4 : Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report.

5 : A meta-analysis comparing eradication, healing and relapse rates in patients with Helicobacter pylori-associated gastric or duodenal ulcer.

6 : Eradication therapy in Helicobacter pylori positive peptic ulcer disease: systematic review and economic analysis.

7 : Upper gastrointestinal bleeding in COVID-19 inpatients: Incidence and management in a multicenter experience from Northern Italy.

8 : A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group.

9 : Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report.

10 : Prophylactic effect of cimetidine in duodenal ulcer disease.

11 : Systematic review and meta-analysis: is 1-week proton pump inhibitor-based triple therapy sufficient to heal peptic ulcer?

12 : Does treatment of Helicobacter pylori with antibiotics alone heal duodenal ulcer? A randomised double blind placebo controlled study.

13 : Antibacterial treatment of gastric ulcers associated with Helicobacter pylori.

14 : Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use.

15 : A systematic approach for the diagnosis and treatment of idiopathic peptic ulcers.

16 : Cigarette smoking and gastrointestinal diseases: the causal relationship and underlying molecular mechanisms (review).

17 : The role of endoscopy in the management of patients with peptic ulcer disease.

18 : Detection of gastric cancer by repeat endoscopy within a short time after negative examination.

19 : The long term results of endoscopic surveillance of premalignant gastric lesions.

20 : Follow-up endoscopy for benign-appearing gastric ulcers has no additive value in detecting malignancy: It is time to individualise surveillance endoscopy.

21 : Does endoscopic follow-up improve the outcome of patients with benign gastric ulcers and gastric cancer?

22 : Prognostic significance of alarm symptoms in patients with gastric cancer.

23 : Endoscopic follow-up study of gastric ulcer to detect malignancy: is it worthwhile?

24 : Effects of gastroprotectant drugs for the prevention and treatment of peptic ulcer disease and its complications: a meta-analysis of randomised trials.

25 : Meta-analysis: Helicobacter pylori eradication therapy vs. antisecretory non-eradication therapy for the prevention of recurrent bleeding from peptic ulcer.

26 : Efficacy of continuous therapy for peptic ulcer in controlled clinical trials.

27 : Long term treatment of duodenal ulcer. A review of management options.

28 : Omeprazole 20 mg three days a week and 10 mg daily in prevention of duodenal ulcer relapse. Double-blind comparative trial.

29 : Review article: maintenance treatment with H2-receptor antagonists for peptic ulcer disease.

30 : A decade of experience with long-term continuous treatment of peptic ulcers with H2-receptor antagonists.

31 : Peptic ulcer disease.

32 : American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy.

33 : Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis.

34 : Helicobacter pylori infection: a predictor of vomiting severity in pregnancy and adverse birth outcome.

35 : The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis.

36 : Use of proton-pump inhibitors in early pregnancy and the risk of birth defects.

37 : The safety of fetal exposure to proton-pump inhibitors during pregnancy.

38 : Omeprazole for refractory gastroesophageal reflux disease during pregnancy and lactation.

39 : Excretion of pantoprazole in human breast.

40 : Use of proton pump inhibitors during pregnancy and breastfeeding.

41 : Asymptomatic gastric ulcer: a follow-up study in patients with previous gastric ulcer disease.

42 : The relationship between suppression of acidity and gastric ulcer healing rates.

43 : Is there an optimal degree of acid suppression for healing of duodenal ulcers? A model of the relationship between ulcer healing and acid suppression.

44 : Natural history of duodenal ulcer detected by the gastric mass surveys in men over 40 years of age.

45 : Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: a review.

46 : Has the impact of Helicobacter pylori therapy on ulcer recurrence in the United States been overstated? A meta-analysis of rigorously designed trials.

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