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Interactive diabetes case 18: A 61-year-old patient with type 2 diabetes and a recent change in diet (medical nutrition therapy) – B1

Interactive diabetes case 18: A 61-year-old patient with type 2 diabetes and a recent change in diet (medical nutrition therapy) – B1
Author:
Lloyd Axelrod, MD
Literature review current through: May 2025. | This topic last updated: Jun 16, 2024.

ANSWER — 

Correct.

Two or more servings of fish (particularly fatty fish) per week are a beneficial and safe element of the diet of patients with diabetes [1,2].

The Nurses' Health Study investigated the effect of fish and long-chain omega-3 fatty acid intake on the risk of coronary heart disease and total mortality in 5103 female nurses with type 2 diabetes but no evidence of cardiovascular disease or cancer at baseline [3]. This study demonstrated that a higher consumption of fish and long-chain omega-3 fatty acids is associated with a lower incidence of coronary heart disease and total mortality among women with diabetes.

The American Diabetes Association (ADA) endorses the benefits of dietary omega-3 fatty acids in diabetes [4]. The position statement "Nutrition Therapy Recommendations for the Management of Adults With Diabetes" states, "As recommended for the general public, an increase in foods containing long-chain omega-3 fatty acids (EPA and DHA) (from fatty fish)… is recommended for individuals with diabetes because of their beneficial effects on lipoproteins, prevention of heart disease, and associations with positive health outcomes in observational studies. The recommendation for the general public to eat fish (particularly fatty fish) at least two times (two servings) per week is also appropriate for people with diabetes" [2].

The evidence from the general population supports the consumption of fish and fish oils for the prevention of cardiovascular disease and sudden death [5-11]. The evidence in support of this statement, the possible mechanisms of the beneficial effects, and the current recommendations of the American Heart Association (AHA) have been reviewed [7,9,11].

  1. Axelrod L. Omega-3 fatty acids in diabetes: gift from the sea?. In: Commentaries on Perspectives in Diabetes (1988-1992), Robertson RP (Ed), American Diabetes Association, Alexandria, VA 2006. Vol 1, p.43.
  2. Evert AB, Boucher JL, Cypress M, et al. Nutrition therapy recommendations for the management of adults with diabetes. Diabetes Care 2013; 36:3821.
  3. Hu FB, Cho E, Rexrode KM, et al. Fish and long-chain omega-3 fatty acid intake and risk of coronary heart disease and total mortality in diabetic women. Circulation 2003; 107:1852.
  4. Evert AB, Dennison M, Gardner CD, et al. Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report. Diabetes Care 2019; 42:731.
  5. Albert CM, Campos H, Stampfer MJ, et al. Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med 2002; 346:1113.
  6. Hu FB, Bronner L, Willett WC, et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 2002; 287:1815.
  7. Kris-Etherton PM, Harris WS, Appel LJ, American Heart Association. Nutrition Committee. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002; 106:2747.
  8. Wang C, Harris WS, Chung M, et al. n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. Am J Clin Nutr 2006; 84:5.
  9. Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA 2006; 296:1885.
  10. Yokoyama M, Origasa H, Matsuzaki M, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 2007; 369:1090.
  11. Fish and Omega-3 Fatty Acids. American Heart Association. Available at: http://www.heart.org/en/healthy-living/healthy-eating/eat-smart/fats/fish-and-omega-3-fatty-acids (Accessed on June 08, 2024).
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