ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

Postnatal use of glucocorticoids for prevention of bronchopulmonary dysplasia (BPD) in preterm infants

Postnatal use of glucocorticoids for prevention of bronchopulmonary dysplasia (BPD) in preterm infants
Literature review current through: Jan 2024.
This topic last updated: May 04, 2022.

INTRODUCTION — Clinical trials have shown that postnatal systemic glucocorticoid therapy improves short-term lung function and pulmonary outcome of infants with established bronchopulmonary dysplasia (BPD) and reduces the risk of BPD in high-risk preterm infants. However, systemic glucocorticoid administration (primarily dexamethasone) is associated with serious adverse effects (eg, increased risk of cerebral palsy [CP]). As a result, the potential benefits of routine administration of postnatal glucocorticoids appear to be outweighed by its downsides. Nevertheless, low-dose systemic glucocorticoid therapy may be beneficial in a select subset of patients (ie, those with evolving or established BPD who remain ventilator-dependent at two to four weeks after birth). (See "Bronchopulmonary dysplasia (BPD): Clinical features and diagnosis", section on 'Epidemiology'.)

The use of postnatal glucocorticoid therapy in preterm infants to prevent BPD will be reviewed here. Antenatal glucocorticoid therapy, a broader discussion of strategies to prevent BPD, and management of established BPD are discussed separately:

(See "Antenatal corticosteroid therapy for reduction of neonatal respiratory morbidity and mortality from preterm delivery".)

(See "Bronchopulmonary dysplasia (BPD): Prevention".)

(See "Bronchopulmonary dysplasia (BPD): Management and outcome".)

DEFINITIONS

Prematurity – Different degrees of prematurity are defined by gestational age (GA), which is calculated from the first day of the mother's last period, or birth weight (BW), as summarized in the table (table 1) and discussed in detail separately. (See "Preterm birth: Definitions of prematurity, epidemiology, and risk factors for infant mortality", section on 'Definitions'.)

BPD – BPD is a chronic lung disease characterized disruption of pulmonary development and/or lung injury in the context of preterm birth. Clinically, BPD is defined as an ongoing need for supplemental oxygen and/or respiratory support at either 28 days postnatal age or 36 weeks postmenstrual age (PMA) in a preterm neonate with radiographic evidence of parenchymal lung disease (image 1). Various criteria are used to define BPD, as summarized in the (table 2) and discussed in detail separately. (see "Bronchopulmonary dysplasia (BPD): Clinical features and diagnosis", section on 'Definitions and severity of BPD').

Neurodevelopmental impairment (NDI) – NDI is a broad term that generally includes cognitive, motor, sensory, behavioral, and/or psychologic impairments. Severe NDI is commonly defined in research studies as the presence of any of the following:

Cognitive delay (ie, ≥2 standard deviations (SD) below the mean on standardized assessments)

Moderate to severe cerebral palsy (CP)

Severe bilateral hearing loss

Severe visual impairment

NDI in preterm infants is discussed in greater detail separately. (See "Long-term neurodevelopmental impairment in infants born preterm: Epidemiology and risk factors".)

SYSTEMIC GLUCOCORTICOIDS

Rationale — Because inflammation is thought to play a key role in the pathogenesis of BPD, the use of glucocorticoids to suppress inflammation has been of an area of active clinical research [1]. (See "Bronchopulmonary dysplasia (BPD): Clinical features and diagnosis", section on 'Pathogenesis'.)

In addition, relative adrenal insufficiency has been described in extremely preterm (EPT) infants (gestational age [GA] <28 weeks) due to impaired synthesis or release of adrenocortical hormones and this may contribute to hemodynamic and respiratory instability in the early postnatal course [2]. It has been suggested that administration of low-dose glucocorticoid therapy as a replacement for this relative deficiency may have a beneficial effect. (See "Neonatal shock: Management", section on 'Suspected adrenal insufficiency'.)

Our approach — Our approach in the use of postnatal systemic glucocorticoid therapy to prevent BPD is based on review of the available literature and is consistent with the recommendations of restrictive use of systemic glucocorticoid therapy to prevent BPD in the preterm infant by both the American Academy of Pediatrics and the Canadian Paediatric Society (AAP/CPS) [3,4] (see 'General efficacy' below):

We recommend against the routine use of postnatal systemic glucocorticoids to prevent BPD for all EPT infants at risk for BPD. Although prophylactic systemic glucocorticoids reduce the risk of BPD, this approach would unnecessarily expose the majority of EPT infants, who would not develop BPD, to the known short-term and long-term adverse effects of glucocorticoids. (See 'General efficacy' below and 'Adverse effects' below.)

We suggest using systemic glucocorticoids selectively in EPT infants who remain ventilator-dependent at a postnatal age of two to four weeks and in whom attempts to wean from the ventilator have failed and/or who require oxygen supplementation >50 percent [5-7]. These infants are at high risk for developing BPD.

In this setting, we administer low-dose dexamethasone according to the protocol used in DART (Dexamethasone: A Randomized Trial) (see 'Dosing' below). Parents/caregivers should be informed of the risks and benefits and should participate in decision-making.

We also reserve the use of systemic glucocorticoid for "rescue therapy" in select older infants (≥36 weeks postmenstrual age [PMA]) with established BPD who require sustained ventilatory and oxygen support or are experiencing an episode of acute pulmonary deterioration. Such infants should first be evaluated for other causes of lung disease, including ventilator-associated pneumonia, progressive pulmonary hypertension, or the development of bronchomalacia. Use of glucocorticoids in this setting is discussed separately. (See "Bronchopulmonary dysplasia (BPD): Management and outcome", section on 'Glucocorticoids'.)

General efficacy — The efficacy of postnatal systemic glucocorticoid therapy, either routinely administered during the first week after birth or used selectively in older infants with ongoing mechanical ventilator-dependence, for preventing development of BPD is supported by clinical trials and meta-analyses [8-12]. In general, the available evidence suggests that the benefits of routine postnatal systemic glucocorticoid therapy are outweighed by the adverse effects. (See 'Adverse effects' below.).

Early use (within first 7 to 10 days) – In a meta-analysis of 26 trials (4167 neonates), early glucocorticoid therapy administered within the first 7 to 10 days after birth decreased the incidence of BPD at 36 weeks PMA compared with placebo (25 versus 31 percent; relative risk [RR] 0.80, 95% CI 0.73-0.88) [9]. Mortality was similar in both groups. As discussed below, the beneficial effect in reducing rates of BPD was seen only in trials of dexamethasone, whereas trials involving hydrocortisone did not detect a significant reduction in BPD. (See 'Dexamethasone' below and 'Hydrocortisone' below.)

However, early glucocorticoid therapy, particularly with dexamethasone, is associated with increased risk of cerebral palsy (CP) in long-term follow-up. Glucocorticoid therapy is also associated with an increased risk of gastrointestinal perforation, as discussed below. (See 'Adverse effects' below.)

Later use in infants with evolving or established BPD – In a meta-analysis of 21 trials involving 1428 infants >7 days old with ongoing ventilator dependence, late administration of glucocorticoid therapy reduced mortality compared with control (18 versus 23 percent; RR 0.81, 95% CI 0.66-0.99), and reduced the incidence of BPD at 36 weeks PMA (53 versus 59 percent, RR 0.89, 95% CI 0.80-0.99; 14 trials, 988 neonates) [11]. In subgroup analyses, a significant reduction in BPD was detected in trials using dexamethasone but not in trials using hydrocortisone. (See 'Dexamethasone' below and 'Hydrocortisone' below.)

Adverse effects

Short-term — In the previously mentioned meta-analyses, postnatal systemic glucocorticoids were associated with the following short-term adverse effects [9,11]:

Hyperglycemia

Hypertension

Gastrointestinal bleeding

Gastrointestinal perforation

Hypertrophic cardiomyopathy

Two trials were stopped early because of increased rates of intestinal perforation in the active treatment groups compared with placebo; one of these trials involved hydrocortisone [13], the other dexamethasone [14]. In a meta-analysis of 16 trials, early glucocorticoid treatment was associated with a higher incidence of intestinal perforation compared with placebo (7 versus 4 percent; RR 1.84, 95% CI 1.36-2.49) [9]. The risk was similar regardless of agent (dexamethasone or hydrocortisone). A separate meta-analysis examining late glucocorticoid treatment was inconclusive as to the risk of intestinal perforation as there were few events (16 total events out of 552 neonates) [11]. The risk of intestinal perforation is heightened when glucocorticoids are administered concomitantly with indomethacin.

Long-term — Follow-up studies have raised concerns that postnatal systemic glucocorticoid therapy contributes to neurodevelopmental impairment (NDI), especially CP [15-18]. In a meta-analysis of trials involving early administration of glucocorticoids (within first seven days after birth), long-term data showed early glucocorticoid treatment was associated with increased risk CP compared with control (11 versus 7 percent; RR 1.42, 95% CI 1.06-1.91) [9]. However, as discussed below, the increased risk of CP was seen only in trials involving dexamethasone, not in trials involving hydrocortisone. (See 'Dexamethasone' below and 'Hydrocortisone' below.)

Specific agents

Dexamethasone — Dexamethasone is the glucocorticoid agent most commonly used in the prevention and treatment of BPD. Randomized clinical trials have shown that it reduces the risk of BPD [9-11,19]. However, postnatal dexamethasone therapy is associated with serious adverse effects, including CP, especially when high doses are used within the first week after birth [9,10,19]. As a result, we continue to recommend against routine early dexamethasone therapy [20]. However, the benefit-risk ratio depends on the underlying risk of BPD [16,21]. In high-risk patients (ie, older infants with evolving or established BPD who remain ventilator-dependent after two to four weeks), the benefits of low-dose dexamethasone likely outweigh the risk of adverse effects [11,22]. (See 'Our approach' above.)

Early use (within first 7 to 10 days) – Randomized trials and meta-analyses evaluating dexamethasone given early (within the first 7 to 10 days after birth) have reported the following findings [9,10,14,19]:

No apparent effect on mortality – In a meta-analysis of 20 trials (n=2940 neonates), mortality rates were similar in infants randomized to early dexamethasone treatment compared with control (24 percent each; RR 1.02, 95% CI 0.90-1.16) [9].

Lower incidence of BPD at 36 weeks PMA – A meta-analysis of 17 trials (n=2791 neonates) early dexamethasone therapy reduced rates of BPD at 36 weeks PMA compared with control (19 versus 27 percent; RR 0.72, 95% CI 0.63-0.82) [9].

Increased incidence of NDI – In a meta-analysis of seven trials (n=921 neonates), rates of CP were higher among infants who received early dexamethasone treatment compared with control (16 versus 9 percent; RR 1.77, 95% CI 1.21-2.58) [9]. Rates of major neurosensory disability (ie, hearing or vision impairment) were also higher in the dexamethasone group (22 versus 16 percent; RR 1.37, 95% CI 1.03-1.83). Other neurodevelopmental outcomes (eg, standardized cognitive and motor assessments) were not consistently reported in the different trials.

Later use (after first 7 to 10 days) – Randomized trials and meta-analyses evaluating use of dexamethasone in neonates who remain ventilator-dependent beyond the first 7 to 10 days after birth have reported the following findings [8,10,11,17,23]:

Uncertain effect on mortality – A meta-analysis of 19 randomized trials (n=993 neonates) did not detect a difference in mortality between infants treated with late dexamethasone compared with control (16 versus 19 percent; RR 0.85, 95% CI 0.66-1.11) [11].

Reduced incidence of BPD at 36 weeks PMA – In a meta-analysis of 12 randomized trials (n=553 neonates), late dexamethasone therapy reduced the incidence of BPD at 36 weeks PMA compared with control (50 versus 66 percent; RR 0.76, 95% CI 0.66-0.87) [11].

Earlier extubation – In a meta-analysis of 16 randomized trials (n=783 neonates), infants treated with late dexamethasone were less likely to remain intubated after seven days of treatment (55 versus 83 percent; RR 0.66, 95% CI 0.6-0.73) [11]. Similar findings were reported in an observational study in which approximately 80 percent of treated infants were successfully extubated within 14 days of starting dexamethasone [24].  

Uncertain effect on NDI – A meta-analysis of 17 randomized trials (n=1290 neonates), did not detect a significant difference in rates of CP in later childhood among neonates treated with late dexamethasone compared with control (14 versus 12 percent; RR 1.12, 95% CI 0.79-1.60) [11].

Hydrocortisone — When a decision is made to treat with glucocorticoids, we generally prefer low-dose dexamethasone over hydrocortisone. Clinical trials directly comparing the two agents are lacking. Although the available trials evaluating hydrocortisone in this setting suggest that the risk of NDI may be lower with this agent, its efficacy for reducing BPD among neonates with ongoing ventilator dependence is less certain. Some of the uncertainty in this area stems from the considerable variability between trials regarding the timing and dosing of hydrocortisone.

Early use (within first 7 to 10 days) – Randomized trials and meta-analyses evaluating hydrocortisone given early (within the first 7 to 10 days after birth) at a low dose (1 to 2 mg/kg per day) have reported the following findings [9,25-30]:

Reduced mortality – In a meta-analysis of 11 randomized trials (n=1433 neonates) early treatment with hydrocortisone reduced in-hospital mortality compared with control (18 versus 22 percent; RR 0.80, 95% CI 0.65-0.99) [9].

No apparent effect on rates of BPD at 36 weeks PMA – A meta-analysis of nine randomized trials (n=1376 neonates) did not detect a significant difference in rates of BPD at 36 weeks PMA among neonates treated with early hydrocortisone compared with control (35 versus 38 percent; RR 0.92, 95% CI 0.81-1.06) [9].

No apparent effect on rates of NDI – In a meta-analysis of six randomized trials (n=1052 neonates), rates of cerebral palsy (CP) in later childhood were similar in both groups (6 percent each; RR 1.05, 95% CI 0.66-1.66), as were rates of neurosensory disability (ie, hearing or vision impairment) (15 versus 17 percent; RR 0.86, 95% CI 0.64-1.14) [9]. Other neurodevelopmental outcomes (eg, standardized cognitive and motor assessments) were not consistently reported in the different trials. In the largest trial, which included 523 EPT infants, neurodevelopmental outcomes at a median corrected age of 22 months were similar in both groups (rates of moderate to severe NDI were 7 versus 11 percent; rates of mild NDI were 20 versus 18 percent) [30]. In a subgroup analysis limited to infants born at 24 to 25 weeks GA, the rate of NDI was lower in infants randomized to hydrocortisone compared with placebo, but the exploratory nature of this subgroup analysis and the small number of events preclude drawing firm conclusions [31]. Magnetic resonance imaging (MRI) at term equivalent age performed in 300 of the 412 survivors demonstrated a higher score for white matter abnormality for the hydrocortisone versus control groups [32]. However, after adjusting for GA and other risk factors, MRI scores were similar between the two groups. Observational studies have also generally reported similar neurodevelopmental outcomes in preterm infants treated with or without hydrocortisone [33-36]; although some studies have reported worse neurodevelopmental outcomes among hydrocortisone-treated infants [28].

Later use (after first 7 to 10 days) – Randomized trials and meta-analyses evaluating use of hydrocortisone at higher doses (3 to 5 mg/kg per day) in neonates who remain ventilator-dependent beyond the first 7 to 10 days after birth have reported the following findings [11,37-40]:

Uncertain effect on mortality – In a meta-analysis of two randomized trials (n=435 neonates) mortality was lower among neonates treated with late hydrocortisone compared with control; however the finding was not statistically significant (23 versus 30 percent; RR 0.74, 95% CI 0.54-1.02) [11]. In a subsequent randomized trial published after the meta-analysis, in-hospital mortality was similar in neonates who received late hydrocortisone treatment (at 14 to 28 days) compared with placebo (9 versus 10 percent; RR 0.86, 95% CI 0.56-1.31) [38].

No apparent effect on rates of BPD at 36 weeks PMA – In a meta-analysis of two randomized trials (n=435 neonates), rates of BPD at 36 weeks PMA were similar in both groups (57 versus 52 percent; RR 1.10, 95% CI 0.92-1.31) [11]. Similar findings were reported in a subsequent randomized trial published after the meta-analysis, in which rates of BPD at 36 weeks PMA were comparable in both groups (83 versus 86 percent; RR 0.96, 95% CI 0.91-1.02) [38].

Earlier extubation – In the two trials that reported extubation rates, infants treated with late hydrocortisone were more likely to be extubated within one to two weeks after starting treatment [37,38]. For example, in a multicenter trial involving 800 infants <30 weeks GA who were ventilator-dependent at 14 to 28 days postnatal age, more infants in the hydrocortisone group were successfully extubated during the 10-day treatment period compared with placebo (45 versus 34 percent; RR 1.54, 95% CI 1.23-1.93) [38].

No apparent effect on rates of NDI – A meta-analysis of two randomized trials (n=435 neonates), did not detect a significant difference in rates of CP in later childhood among neonates treated with late hydrocortisone compared with control (28 versus 34 percent; RR 0.82, 95% CI 0.62-1.08) [11]. Similarly, in a subsequent randomized trial published after the meta-analysis, rates of moderate to severe NDI among survivors were comparable in both groups (58 versus 57 percent; RR 1.03, 95% CI 0.90-1.17) [38].

Dosing — The risk of adverse effects of glucocorticoid therapy appears to increase with increasing cumulative dose [20,41,42]. An optimal dose that provides maximal benefit while minimizing adverse effects has not been established. Decisions regarding criteria for starting postnatal glucocorticoid therapy, preferred agent, and dosing remain center dependent. In our centers, we selectively use low-dose dexamethasone only in patients who are at high risk of developing BPD (ie, ventilator- or oxygen-dependent after two to four weeks postnatal age). (See 'Our approach' above.)

We administer low-dose dexamethasone according to the protocol used in DART (Dexamethasone: A Randomized Trial), which provides intravenous dexamethasone (cumulative dose 0.89 mg/kg) as follows [8]:

0.075 mg/kg per dose 12 hourly for three days, then,

0.05 mg/kg per dose 12 hourly for three days, then,

0.025 mg/kg per dose 12 hourly for two days, then,

0.01 mg/kg per dose 12 hourly for two days, then discontinue

Several cohort studies have reported an increasing risk of neurologic impairment with higher doses of glucocorticoid therapy or longer duration of therapy:

A multicenter prospective cohort study reported that for infants exposed to postnatal glucocorticoid therapy (dexamethasone in 92 percent of cases) an increase of 1 mg/kg in dexamethasone dose was associated with a two-point reduction in the Bayley mental development index (MDI) score, and a 40 percent increase in risk for disabling CP at 18 to 22 months corrected age [41].

In the EPICure study (a large English prospective cohort study of preterm infants born <26 weeks gestation), increasing duration of postnatal steroid treatment was associated with poor motor outcomes. [42].

In a network meta-analysis that included 14 trials that used different glucocorticoid regimens (ie, different agents [dexamethasone or hydrocortisone], timing of administration [early versus late], and/or cumulative daily dose [low, moderate, or high]), dexamethasone given between 8 to 14 days after birth at moderate dose was the regimen associated with lowest risk of BPD or morality at a PMA of 36 weeks compared with the other 13 regimens [43]. However, the indirect nature of these comparisons limit the certainty of this finding.

Trends in practice over time — The use of postnatal systemic glucocorticoid therapy in preterm neonates has declined considerably since the late 1990s and early 2000s when concerns first surfaced about long-term adverse effects. There was further decline after 2010 when the AAP published guidelines recommending against postnatal glucocorticoid therapy due to these concerns.

Several population-based studies examining the impact of diminished glucocorticoid use on the incidence and severity of BPD have reported conflicting results. A study of three large neonatal network databases in North America reported that a reduction in steroid use starting in 1999 was not associated with significant changes in mortality or the incidence and severity of BPD [44]. In contrast, several studies have reported an increase in the incidence of BPD with varying effects on mortality. One retrospective study of extremely low birth weight (ELBW) infants (BW <1000 g) reported that decreased use of postnatal glucocorticoid therapy was associated with an increase in the incidence of BPD without a change in mortality [45]. There was also no change in the rate of major NDI. In another population-based study found a reduction in postnatal glucocorticoid use was associated with a decrease in mortality and an increased incidence of BPD for preterm infants (GA 24 to 32 weeks) [46]. These findings support the notion that prophylactic glucocorticoids are effective in reducing the incidence of BPD. (See 'General efficacy' above.)

Unanswered questions — As discussed in the previous sections, we recommend against routine use of postnatal glucocorticoid therapy since the available evidence suggests that the potential benefits do not outweigh the known complications of this intervention [3,4]. However, it remains uncertain whether there is a clinical setting in which postnatal glucocorticoid therapy would be beneficial despite the risk of adverse effects.

Well-powered randomized controlled trials with adequate follow-up are still needed to answer the following questions [47]:

Can we identify a subpopulation of preterm infants for whom the benefits of postnatal glucocorticoids clearly outweigh the risks?

If glucocorticoid therapy is used, what is the optimal regimen (ie, agent, timing, dosing)? (See 'Specific agents' above and 'Dosing' above.)

Do short-term improvements in pulmonary function associated with glucocorticoid administration convey additional long-term pulmonary benefits (eg, prevention of long-term severe pulmonary complications of BPD, including severe pulmonary hypertension and cor pulmonale)? (See "Complications and long-term pulmonary outcomes of bronchopulmonary dysplasia".)

OTHER ROUTES OF ADMINISTRATION

Inhaled glucocorticoids — It has been proposed that inhaled glucocorticoids might be an effective and safer alternative for preventing BPD in at-risk EPT infants rather than using systemic glucocorticoids, since the latter is associated with long-term neurodevelopmental impairment (NDI), as discussed above (see 'Adverse effects' above). However, postnatal administration of inhaled glucocorticoids has not consistently been shown to reduce the risk of BPD, and there are concerns about a possible increased mortality risk.

Our approach — Our approach is as follows:

Routine use for prevention of BPD – Based upon available data (described below), we suggest not routinely using inhaled glucocorticoids to prevent BPD.

For treatment of severe BPD – Despite the limited data on the efficacy of inhaled glucocorticoids, we do selectively use inhaled glucocorticoids in older infants if they have severe BPD, are dependent upon substantial ventilator and oxygen support, and have signs of severe airway obstruction or reactive airway disease. This is discussed separately. (See "Bronchopulmonary dysplasia (BPD): Management and outcome", section on 'Glucocorticoids'.)

Evidence — Based on the available clinical trial data, postnatal administration of inhaled glucocorticoids does not appear to meaningfully reduce the risk of BPD, and some studies suggest a possible increased mortality risk [48-50].

In a meta-analysis of six trials involving mechanically ventilated preterm neonates randomized to early (in the first two weeks after birth) inhaled glucocorticoid therapy or placebo, rates of BPD at 28 days of age or 36 weeks postmenstrual age (PMA) were similar in both groups (15 percent in each; relative risk [RR] 0.97, 95% CI 0.62-1.52) [48]. Mortality was also similar at 36 weeks PMA (14 and 15 percent, respectively). However, inhaled glucocorticoids reduced the incidence of BPD among survivors (24 versus 31 percent; RR 0.76, 95% CI 0.63-0.93). Adverse events were similar between the two groups.

The largest trial in the above meta-analysis was the NEUROSIS trial (Neonatal EUROpean Study of Inhaled Steroids). A follow-up study of the NEUROSIS trial reported that of the 813 infants for whom vital status was known at two years, there were more deaths in the inhaled glucocorticoid group compared with placebo (20 versus 15 percent; RR 1.37 95% CI 1.01-1.86) [49]. Rates of NDI among survivors were similar in both groups (48 versus 51 percent; adjusted RR 0.93, 95% CI 0.80-1.09).

There are fewer data on use of late (>7 days after birth) inhaled glucocorticoid therapy in preterm neonates with ongoing need for mechanical ventilation or oxygen beyond the first week after birth. In a meta-analysis five placebo-controlled trials (n=79), infants who received late inhaled glucocorticoid therapy were less likely to remain intubated after seven days of treatment (74 versus 95 percent; RR 0.80, 95% CI 0.66-0.98) [50]. However, overall duration of mechanical ventilation was similar in both groups. No firm conclusions could be reached regarding the effect of inhaled glucocorticoids on mortality, rates of BPD at 36 weeks PMA, or serious adverse events because these outcomes were inconsistently reported and/or there were few events. Another important limitation of these data is the considerable heterogeneity between trials. In addition, most of the trials were performed in the late 1990s to early 2000s and the applicability to modern-day practice is unclear.

Intratracheal glucocorticoids — Because of the concerns for adverse effects associated with systemic steroids (eg, increased risk of cerebral palsy), postnatal intratracheal delivery of glucocorticoids mixed with surfactant was proposed as an alternative. However, we suggest not using this approach as it remains uncertain whether intratracheal glucocorticoid therapy is effective and safe in extremely preterm (EPT) neonates at risk for BPD.

Two randomized controlled trials from a single center examined early administration of intratracheal budesonide at 0.25 mg/kg mixed in surfactant compared with surfactant alone in infants <1500 g [51-55]. In a meta-analysis that pooled the results of both trials plus three other smaller trials (n=549 infants), rates of BPD were lower in the budesonide group compared with control (22 versus 42 percent; RR 0.58, 95% CI 0.41-0.82) [54]. Short-term mortality was also lower in the budesonide group (13 versus 20 percent; RR 0.64, 95% CI 0.41-0.99). A separate meta-analysis assessing long-term outcomes at age 18 to 36 months did not detect a difference in rates of neurodevelopmental impairment (31 versus 39 percent; RR 0.78, 95% CI 0.55-1.11) or long-term mortality (18 versus 24 percent; RR 0.76, 95% CI 0.52-1.11). [56].

The results of these trials need to be replicated in larger multicenter trials before use of intratracheal budesonide can be recommended as a routine.

SOCIETY GUIDELINE LINKS — Links to society and government-sponsored guidelines from selected countries and regions around the world are provided separately. (See "Society guideline links: Bronchopulmonary dysplasia".)

SUMMARY AND RECOMMENDATIONS

Rationale for postnatal glucocorticoid therapy ‒ Because inflammation is thought to play a key role in the pathogenesis of bronchopulmonary dysplasia (BPD), the use of glucocorticoids to suppress inflammation has been proposed to prevent BPD in high-risk preterm infants, particularly extremely preterm (EPT) infants (<28 weeks gestation). (See 'Rationale' above.)

Systemic glucocorticoid therapy ‒ The potential benefits of postnatal glucocorticoid therapy must be weighed against the adverse effects, which include hyperglycemia, hypertension, gastrointestinal perforation, and risk of neurodevelopmental impairment (eg, cerebral palsy [CP]). The optimal approach to identifying patients who are likely to benefit from postnatal glucocorticoid therapy, selecting a glucocorticoid agent, timing of treatment, and dosing remain uncertain. Practice varies between centers. Our general approach is as follows (see 'Systemic glucocorticoids' above):

For EPT infants who do not require mechanical ventilation, we recommend against routine use of systemic glucocorticoid therapy (Grade 1B). Although postnatal systemic glucocorticoid therapy reduces the risk of BPD, it is associated with serious adverse effects, particularly increased risk of CP. Thus, the potential benefits of routine postnatal glucocorticoid therapy in this population appear to be outweighed by its downsides. (See 'Our approach' above and 'General efficacy' above and 'Adverse effects' above.)

For EPT infants who remain ventilator- and oxygen-dependent at two to four weeks postnatally, we suggest low-dose systemic glucocorticoid therapy (Grade 2B). In this setting, we suggest low-dose dexamethasone rather than hydrocortisone (Grade 2C). In our center, we use a low-dose 10-day regimen. However, the optimal regimen remains uncertain. (See 'Dexamethasone' above and 'Dosing' above.)

Inhaled and intratracheal glucocorticoid therapy ‒ Because of the concerns for adverse effects associated with systemic steroids, inhaled glucocorticoids and intratracheal administration (delivered mixed with surfactant) have been proposed as alternatives. (See 'Other routes of administration' above.)

We suggest not routinely using these therapies for prevention of BPD (Grade 2C). Postnatal inhaled glucocorticoid therapy has not consistently been shown to reduce the risk of BPD, and there are concerns about a possible increased mortality risk. Data on intratracheal glucocorticoid administration are limited and the safety and efficacy of this approach remain uncertain. (See 'Inhaled glucocorticoids' above and 'Intratracheal glucocorticoids' above.)

Despite the limited data, inhaled glucocorticoid therapy is a reasonable treatment option for older infants with established severe BPD, particularly if they are dependent upon substantial ventilator and oxygen support and have signs of severe airway obstruction or reactive airway disease. This is discussed separately. (See "Bronchopulmonary dysplasia (BPD): Management and outcome", section on 'Glucocorticoids'.)

ACKNOWLEDGMENT — The UpToDate editorial staff acknowledges James Adams, Jr., MD, who contributed to an earlier version of this topic review.

  1. Htun ZT, Schulz EV, Desai RK, et al. Postnatal steroid management in preterm infants with evolving bronchopulmonary dysplasia. J Perinatol 2021; 41:1783.
  2. Fernandez EF, Watterberg KL. Relative adrenal insufficiency in the preterm and term infant. J Perinatol 2009; 29 Suppl 2:S44.
  3. Watterberg KL, American Academy of Pediatrics. Committee on Fetus and Newborn. Policy statement--postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia. Pediatrics 2010; 126:800.
  4. Lemyre B, Dunn M, Thebaud B. Postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia in preterm infants. Paediatr Child Health 2020; 25:322.
  5. Doyle LW, Ehrenkranz RA, Halliday HL. Dexamethasone treatment after the first week of life for bronchopulmonary dysplasia in preterm infants: a systematic review. Neonatology 2010; 98:289.
  6. Dassios T, Kaltsogianni O, Hickey A, et al. Chronology and Determinants of Respiratory Function Changes Following Administration of Systemic Postnatal Corticosteroids in Extremely Preterm Infants. J Pediatr 2019; 215:17.
  7. Buchiboyina AK, Yip CSA, Kohan R, et al. Effect of cumulative dexamethasone dose in preterm infants on neurodevelopmental and growth outcomes: a Western Australia experience. Arch Dis Child Fetal Neonatal Ed 2021; 106:69.
  8. Doyle LW, Davis PG, Morley CJ, et al. Low-dose dexamethasone facilitates extubation among chronically ventilator-dependent infants: a multicenter, international, randomized, controlled trial. Pediatrics 2006; 117:75.
  9. Doyle LW, Cheong JL, Hay S, et al. Early (&lt; 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants. Cochrane Database Syst Rev 2021; 10:CD001146.
  10. Zeng L, Tian J, Song F, et al. Corticosteroids for the prevention of bronchopulmonary dysplasia in preterm infants: a network meta-analysis. Arch Dis Child Fetal Neonatal Ed 2018; 103:F506.
  11. Doyle LW, Cheong JL, Hay S, et al. Late (≥ 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants. Cochrane Database Syst Rev 2021; 11:CD001145.
  12. Shaffer ML, Baud O, Lacaze-Masmonteil T, et al. Effect of Prophylaxis for Early Adrenal Insufficiency Using Low-Dose Hydrocortisone in Very Preterm Infants: An Individual Patient Data Meta-Analysis. J Pediatr 2019; 207:136.
  13. Watterberg KL, Gerdes JS, Cole CH, et al. Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial. Pediatrics 2004; 114:1649.
  14. Stark AR, Carlo WA, Tyson JE, et al. Adverse effects of early dexamethasone treatment in extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. N Engl J Med 2001; 344:95.
  15. O'Shea TM, Kothadia JM, Klinepeter KL, et al. Randomized placebo-controlled trial of a 42-day tapering course of dexamethasone to reduce the duration of ventilator dependency in very low birth weight infants: outcome of study participants at 1-year adjusted age. Pediatrics 1999; 104:15.
  16. Doyle LW, Halliday HL, Ehrenkranz RA, et al. Impact of postnatal systemic corticosteroids on mortality and cerebral palsy in preterm infants: effect modification by risk for chronic lung disease. Pediatrics 2005; 115:655.
  17. Doyle L, Davis P. Postnatal corticosteroids in preterm infants: systematic review of effects on mortality and motor function. J Paediatr Child Health 2000; 36:101.
  18. Barrington KJ. The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs. BMC Pediatr 2001; 1:1.
  19. Doyle LW, Ehrenkranz RA, Halliday HL. Dexamethasone treatment in the first week of life for preventing bronchopulmonary dysplasia in preterm infants: a systematic review. Neonatology 2010; 98:217.
  20. Marlow N. Reevaluating Postnatal Steroids for Extremely Preterm Infants to Prevent Lung Disease. JAMA 2017; 317:1317.
  21. Doyle LW, Halliday HL, Ehrenkranz RA, et al. An update on the impact of postnatal systemic corticosteroids on mortality and cerebral palsy in preterm infants: effect modification by risk of bronchopulmonary dysplasia. J Pediatr 2014; 165:1258.
  22. Jobe AH. Postnatal corticosteroids for bronchopulmonary dysplasia. Clin Perinatol 2009; 36:177.
  23. Kothadia JM, O'Shea TM, Roberts D, et al. Randomized placebo-controlled trial of a 42-Day tapering course of dexamethasone to reduce the duration of ventilator dependency in very low birth weight infants. Pediatrics 1999; 104:22.
  24. Kurtom W, Schmidt A, Jain D, et al. Efficacy of late postnatal dexamethasone on weaning from invasive mechanical ventilation in extreme premature infants. J Perinatol 2021; 41:1951.
  25. Baud O, Maury L, Lebail F, et al. Effect of early low-dose hydrocortisone on survival without bronchopulmonary dysplasia in extremely preterm infants (PREMILOC): a double-blind, placebo-controlled, multicentre, randomised trial. Lancet 2016; 387:1827.
  26. Morris IP, Goel N, Chakraborty M. Efficacy and safety of systemic hydrocortisone for the prevention of bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis. Eur J Pediatr 2019; 178:1171.
  27. Watterberg KL, Shaffer ML, Mishefske MJ, et al. Growth and neurodevelopmental outcomes after early low-dose hydrocortisone treatment in extremely low birth weight infants. Pediatrics 2007; 120:40.
  28. Patra K, Greene MM, Silvestri JM. Neurodevelopmental impact of hydrocortisone exposure in extremely low birth weight infants: outcomes at 1 and 2 years. J Perinatol 2015; 35:77.
  29. Peltoniemi OM, Lano A, Yliherva A, et al. Randomised trial of early neonatal hydrocortisone demonstrates potential undesired effects on neurodevelopment at preschool age. Acta Paediatr 2016; 105:159.
  30. Baud O, Trousson C, Biran V, et al. Association Between Early Low-Dose Hydrocortisone Therapy in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years of Age. JAMA 2017; 317:1329.
  31. Baud O, Trousson C, Biran V, et al. Two-year neurodevelopmental outcomes of extremely preterm infants treated with early hydrocortisone: treatment effect according to gestational age at birth. Arch Dis Child Fetal Neonatal Ed 2019; 104:F30.
  32. Alison M, Tilea B, Toumazi A, et al. Prophylactic hydrocortisone in extremely preterm infants and brain MRI abnormality. Arch Dis Child Fetal Neonatal Ed 2020; 105:520.
  33. Lodygensky GA, Rademaker K, Zimine S, et al. Structural and functional brain development after hydrocortisone treatment for neonatal chronic lung disease. Pediatrics 2005; 116:1.
  34. Rademaker KJ, Uiterwaal CS, Groenendaal F, et al. Neonatal hydrocortisone treatment: neurodevelopmental outcome and MRI at school age in preterm-born children. J Pediatr 2007; 150:351.
  35. Needelman H, Hoskoppal A, Roberts H, et al. The effect of hydrocortisone on neurodevelopmental outcome in premature infants less than 29 weeks' gestation. J Child Neurol 2010; 25:448.
  36. Kersbergen KJ, de Vries LS, van Kooij BJ, et al. Hydrocortisone treatment for bronchopulmonary dysplasia and brain volumes in preterm infants. J Pediatr 2013; 163:666.
  37. Onland W, Cools F, Kroon A, et al. Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation: A Randomized Clinical Trial. JAMA 2019; 321:354.
  38. Watterberg KL, Walsh MC, Li L, et al. Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia. N Engl J Med 2022; 386:1121.
  39. Parikh NA, Kennedy KA, Lasky RE, et al. Pilot randomized trial of hydrocortisone in ventilator-dependent extremely preterm infants: effects on regional brain volumes. J Pediatr 2013; 162:685.
  40. Halbmeijer NM, Onland W, Cools F, et al. Effect of Systemic Hydrocortisone Initiated 7 to 14 Days After Birth in Ventilated Preterm Infants on Mortality and Neurodevelopment at 2 Years' Corrected Age: Follow-up of a Randomized Clinical Trial. JAMA 2021; 326:355.
  41. Wilson-Costello D, Walsh MC, Langer JC, et al. Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants. Pediatrics 2009; 123:e430.
  42. Wood NS, Costeloe K, Gibson AT, et al. The EPICure study: associations and antecedents of neurological and developmental disability at 30 months of age following extremely preterm birth. Arch Dis Child Fetal Neonatal Ed 2005; 90:F134.
  43. Ramaswamy VV, Bandyopadhyay T, Nanda D, et al. Assessment of Postnatal Corticosteroids for the Prevention of Bronchopulmonary Dysplasia in Preterm Neonates: A Systematic Review and Network Meta-analysis. JAMA Pediatr 2021; 175:e206826.
  44. Walsh MC, Yao Q, Horbar JD, et al. Changes in the use of postnatal steroids for bronchopulmonary dysplasia in 3 large neonatal networks. Pediatrics 2006; 118:e1328.
  45. Cheong JL, Anderson P, Roberts G, et al. Postnatal corticosteroids and neurodevelopmental outcomes in extremely low birthweight or extremely preterm infants: 15-year experience in Victoria, Australia. Arch Dis Child Fetal Neonatal Ed 2013; 98:F32.
  46. Shinwell ES, Lerner-Geva L, Lusky A, Reichman B. Less postnatal steroids, more bronchopulmonary dysplasia: a population-based study in very low birthweight infants. Arch Dis Child Fetal Neonatal Ed 2007; 92:F30.
  47. Bose CL, Laughon MM. Corticosteroids and chronic lung disease: time for another randomized, controlled trial? Pediatrics 2005; 115:794.
  48. Shah VS, Ohlsson A, Halliday HL, Dunn M. Early administration of inhaled corticosteroids for preventing chronic lung disease in very low birth weight preterm neonates. Cochrane Database Syst Rev 2017; 1:CD001969.
  49. Bassler D, Shinwell ES, Hallman M, et al. Long-Term Effects of Inhaled Budesonide for Bronchopulmonary Dysplasia. N Engl J Med 2018; 378:148.
  50. Onland W, Offringa M, van Kaam A. Late (≥ 7 days) inhalation corticosteroids to reduce bronchopulmonary dysplasia in preterm infants. Cochrane Database Syst Rev 2017; 8:CD002311.
  51. Yeh TF, Chen CM, Wu SY, et al. Intratracheal Administration of Budesonide/Surfactant to Prevent Bronchopulmonary Dysplasia. Am J Respir Crit Care Med 2016; 193:86.
  52. Yeh TF, Lin HC, Chang CH, et al. Early intratracheal instillation of budesonide using surfactant as a vehicle to prevent chronic lung disease in preterm infants: a pilot study. Pediatrics 2008; 121:e1310.
  53. Kuo HT, Lin HC, Tsai CH, et al. A follow-up study of preterm infants given budesonide using surfactant as a vehicle to prevent chronic lung disease in preterm infants. J Pediatr 2010; 156:537.
  54. Zhong YY, Li JC, Liu YL, et al. Early Intratracheal Administration of Corticosteroid and Pulmonary Surfactant for Preventing Bronchopulmonary Dysplasia in Preterm Infants with Neonatal Respiratory Distress Syndrome: A Meta-analysis. Curr Med Sci 2019; 39:493.
  55. Venkataraman R, Kamaluddeen M, Hasan SU, et al. Intratracheal Administration of Budesonide-Surfactant in Prevention of Bronchopulmonary Dysplasia in Very Low Birth Weight Infants: A Systematic Review and Meta-Analysis. Pediatr Pulmonol 2017; 52:968.
  56. Zheng Y, Xiu W, Lin Y, et al. Long-term effects of the intratracheal administration of corticosteroids for the prevention of bronchopulmonary dysplasia: A meta-analysis. Pediatr Pulmonol 2019; 54:1722.
Topic 5023 Version 65.0

References

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟