Version June 2024
| Tumor type | Criteria |
| Diffuse idiopathic neuroendocrine cell hyperplasia | Multifocal hyperplasia of neuroendocrine cells in bronchiolar epithelium, associated with multiple carcinoid tumorlets (generally less than 5 mm in greatest dimension), with or without obliterative bronchiolitis; and with or without a carcinoid tumor |
| Typical carcinoid | Carcinoid morphology and <2 mitoses/2 mm2 (10 HPFs), lacking necrosis and >0.5 cm |
| Atypical carcinoid | Carcinoid morphology with 2 to 10 mitoses/2 mm2 (10 HPFs) or necrosis (often punctuate) |
| Large cell neuroendocrine carcinoma | Neuroendocrine morphology (organoid nesting palisading rosettes, trabeculae); |
| High mitotic rate >10/2 mm2 (10 HPFs), median of 70/2 mm2; | |
| Necrosis (often large zones); | |
| Cytologic features of a NSCLC: large cell size, low nuclear to cytoplasmic ratio, vesicular or fine chromatin, and/or frequent nucleoli; some tumors have fine nuclear chromatin and lack nucleoli but qualify as NSCLC because of large cell size and abundant cytoplasm; and | |
| Positive immunohistochemical staining for one or more NE markers (other than neuron-specific enolase) and/or NE granules by electron microscopy | |
| Small cell neuroendocrine carcinoma | Small size (generally less than the diameter of three resting lymphocytes); |
| Scant cytoplasm; | |
| Nuclei: finely granular nuclear chromatin, absent or faint nucleoli; | |
| High mitotic rate: >11 mitoses/2 mm2 (10 HPFs), median of 80/2 mm2 (10 HPFs); and | |
| Frequent necrosis, often in large zones |
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