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Fat-soluble vitamin deficiencies and supplementation for patients with cholestasis due to biliary atresia or Alagille syndrome

Fat-soluble vitamin deficiencies and supplementation for patients with cholestasis due to biliary atresia or Alagille syndrome
Fat-soluble vitamin How to monitor Standard oral treatment recommendation Signs and symptoms of deficiency Recommended supplementation in setting of deficiency
Vitamin A

Measure serum or plasma retinol and RBP

Interpretation:

  • Normal range for retinol 19 to 77 mcg/dL
  • Retinol – RBP <0.8 mol/mol defines deficiency when retinol <20 mcg/dL
Liquid vitamin A:
  • <10 kg – 5000 IU/day*
  • ≥10 kg – 10,000 IU/day
  • Keratinization of the skin and mucous membranes
  • Ocular effects such as xerophthalmia, night blindness, xerosis, and bitot spots
  • Retinol:RBP molar ratio <0.8 and serum retinol <20 cgg/dL

Liquid vitamin A 5000 IU/day by mouth; recheck levels in 1 month

or

25,000 to 50,000 IU/day by mouth for 1 to 4 weeks; recheck levels weekly

or

50,000 IU intramuscularly once/month up to 2 months; recheck levels monthly

Vitamin D

Measure serum 25-OH vitamin D

Interpretation:

  • Optimal levels >30 ng/mL
Cholecalciferol or ergocalciferol – 2000 to 5000 IU/day (50 to 125 mcg/day)
  • Rickets, fractures, osteomalacia
  • 25-OH vitamin D <15 ng/mL

Cholecalciferol or ergocalciferol 1200 to 4000 IU/day by mouth; recheck levels in 1 month

If child remains deficient, give 4000 to 8000 IU/day; recheck levels in 1 month

or

Give 1,25-OH2 vitamin D 0.05 to 0.2 mcg/kg/day; recheck serum 1,25-OH2 vitamin D levels in 1 month

Vitamin E

Measure serum vitamin E and total lipids

Interpretation:

  • Normal vitamin E:total lipid ratio >0.6 mg/g (age <1 year) or >0.8 mg/g (age >1 year)
TPGS – 15 to 25 IU/kg/day (10 to 17 mg/kg/day)
  • Peripheral neuropathy, ataxia, ophthalmoplegia
  • Vitamin E:total lipid ratio <0.6 mg/g (age <1 year) or <0.8 mg/g (age >1 year) is deficient
If deficient, 50 IU/kg/day of TPGS; recheck levels in 1 month
Vitamin K Measure PT, INR, and PIVKA-II Vitamin K1 2 to 5 mg daily
  • Prolonged PT, increased INR (INR >1.2), elevated PIVKA-II
  • Coagulopathy, bruising, bleeding
If INR >1.5 and ≤1.8, give 5 mg vitamin K1 daily by mouth and/or 2 to 5 mg vitamin K intramuscularly 1 time; recheck PT/INR in 1 to 2 days
The doses in this table are designed for cholestatic/jaundiced infants and children with biliary atresia or Alagille syndrome. If the cholestasis resolves and vitamins are replete, children can be transitioned to standard doses of multivitamins, with routine monitoring of fat-soluble vitamins as outlined above. These doses are consistent with society guidelines[1].

1,25-OH2 vitamin D: 1,25-dihydroxyvitamin D; 25-OH vitamin D: 25-hydroxyvitamin D; INR: international normalized ratio; IU: international units; PIVKA-II: protein induced by vitamin K absence II; PT: prothrombin time; RBP: retinol-binding protein; TPGS: tocopherol polyethylene glycol 1000 succinate (water-miscible form of vitamin E); vitamin K1: phytonadione.

* For vitamin A, 1 IU = 0.3 micrograms retinol or 0.6 micrograms beta-carotene.

Reference:
  1. Mouzaki M, Bronsky J, Gupte G, et al. Nutrition Support of Children With Chronic Liver Diseases: A Joint Position Paper of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2019; 69:498.
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