Version July 2025
| Features | CRS without NP | CRS with NP | AFRS |
| Nasal polyps | No – Exclusion of polyps is required for diagnosis | Yes – Required for diagnosis* | Yes (in most cases) |
| Allergic mucin | May be present | May be present | Yes – Required for diagnosis |
| Aspirin-associated respiratory disease | Rare | Asthma present in approximately 40% Aspirin intolerance and asthma present in approximately 15% | May be present |
| Evidence of IgE-mediated allergy to fungi | May be present | May be present | Yes – Required for diagnosis |
AFRS: allergic fungal rhinosinusitis; CRS: chronic rhinosinusitis; IgE: immunoglobulin E; NP: nasal polyposis.
* Polyps may be bilateral or unilateral in the setting of bilateral mucosal inflammation. Medical records documenting removal of nasal polyps during previous sinus surgery would also satisfy this requirement.
