Mucus production in irritable bowel syndrome with diarrhea

Increased mucus production as a sign of irritation in patients with irritable bowel syndrome (Panel A) and diarrhea (Panels B, C, and D). In panels A and B, mucus can be seen directly with alcian stain. (Panel D) Disruption of the normally homogenous biostructure of the fecal cylinder and development of multiple striae of slime within the germinal zone demonstrate the increased mucus production (Panels A, B, and C: x100; Panel D: x400).