Methotrexate pneumonitis: Underlying diseases and dose of methotrexate

	Number of patients	Histological study (n = 49)	Dose of MTX (mg/week)
RA	62	24	2.5 to 15
Leukaemia (in remission)	23	8	20 to 80
Cancer (breast, lung, other)	10	9	15 to 1400*
Psoriasis	8	2	2.5 to 37.5
Primary biliary cirrhosis^¶	6	1	15
Lymphoma	3	2	6.25 to 80
Polymyositis	2	1	20 to 50
Ectopic pregnancy	2	0	12.5 to 88^Δ
Asthma	1	1	5 to 15
Mycosis fungoides	1	1	50
Pemphigus vulgaris	1	0	50 to 75
Medulloblastoma	1	0	7.5
Polyarticular juvenile RA	1	0	0.5^◊
Psoriatic arthritis	1	0	15
COPD	1	0	7.5 to 15

RA: rheumatoid arthritis; COPD: chronic obstructive pulmonary disease.
* One patient received ten intrathecal doses of methotrexate at two day intervals.
¶ Primary biliary cirrhosis has been renamed primary biliary cholangitis.
Δ Single intramuscular administration.
◊ mg/kg per week.

Graphic 55765 Version 5.0

خرید پکیج

Methotrexate pneumonitis: Underlying diseases and dose of methotrexate