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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : -19 مورد

Features of 3 of the major subtypes of juvenile idiopathic arthritis (JIA)

Features of 3 of the major subtypes of juvenile idiopathic arthritis (JIA)
  Systemic JIA Oligoarticular JIA Polyarticular JIA
% of JIA patients 10 to 15 50 30 to 40
Sex F = M F>M F>M
Age <17 years, but adult-onset Still's disease can occur in older patients Peak 2 to 3 years, rare >10 Peaks 2 to 5, 10 to 14 years
Joints Any number and any joint 4 or fewer large joints, but rarely hips; may extend to involve more joints Any joint, usually symmetrical, and must involve more than 5 joints
Fever, rash, lymphadenopathy, hepatosplenomegaly Yes No No
Uveitis Rare 20%; most common in patients who are ANA positive 10 to 20%; most common in patients who are ANA positive
Laboratory abnormalities
  • White blood cell count
Elevated with neutrophil predominance Normal Normal
  • Hemoglobin
Commonly low Normal Normal
  • ESR
Very elevated, unless there is MAS (paradoxically drops due to fibrinogen consumption) Usually not elevated May be mild to moderately elevated
  • ANA
Negative Positive low titer (1:40 to 1:80) common Positive low titer (1:40 to 1:80) common, especially in younger children
  • Rheumatoid factor
Negative Negative 10 to 20% in those >10 years
  • Ferritin
Commonly extremely elevated (often >1000 ng/mL) Normal May be mildly elevated
Response to methotrexate Poor to moderate Excellent Excellent
Response to biologic drugs

Poor to TNF inhibitors

Excellent to IL-1 and IL-6 inhibitors

Excellent to TNF inhibitors and IL-6 inhibitors

Poor to IL-1 inhibitors

Excellent to TNF inhibitors and IL-6 inhibitors

Poor to IL-1 inhibitors

ANA: antinuclear antibody; ESR: erythrocyte sedimentation rate; F: female; IL: interleukin; M: male; MAS: macrophage activation syndrome; TNF: tumor necrosis factor.
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