Version June 2024
| Systemic JIA | Oligoarticular JIA | Polyarticular JIA | |
| Percent of JIA patients | 10 to 15 | 50 | 30 to 40 |
| Sex | F = M | F>M | F>M |
| Age | <17 years, but adult-onset Still's disease can occur in older patients | Peak 2 to 3 years, rare >10 | Peaks 2 to 5, 10 to 14 years |
| Joints | Any number and any joint | 4 or fewer large joints, but rarely hips; may extend to involve more joints | Any joint, usually symmetrical, and must involve more than 5 joints |
| Fever, rash, lymphadenopathy, hepatosplenomegaly | Yes | No | No |
| Uveitis | Rare | 20%; most common in patients who are ANA positive | 10 to 20%; most common in patients who are ANA positive |
| Laboratory abnormalities | |||
| - White blood cell count | Elevated with neutrophil predominance | Normal | Normal |
| - Hemoglobin | Commonly low | Normal | Normal |
| - ESR | Very elevated, unless there is MAS (paradoxically drops due to fibrinogen consumption) | Usually not elevated | May be mild to moderately elevated |
| - ANA | Negative | Positive low titer (1:40 to 1:80) common | Positive low titer (1:40 to 1:80) common, especially in younger children |
| - Rheumatoid factor | Negative | Negative | 10 to 20% in those >10 years |
| - Ferritin | Commonly extremely elevated (often >1000 ng/mL) | Normal | May be mildly elevated |
| Response to methotrexate | Poor to moderate | Excellent | Excellent |
| Response to biologic drugs | Poor to TNF inhibitors Excellent to IL-1 and IL-6 inhibitors | Excellent to TNF inhibitors and IL-6 inhibitors Poor to IL-1 inhibitors | Excellent to TNF inhibitors and IL-6 inhibitors Poor to IL-1 inhibitors |
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