Antimicrobial regimens | |
Our preferred regimen | Alternative options |
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For patients with potential severe hypersensitivity to beta-lactam antibiotics (eg, penicillin, cephalosporin):
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For patients with nonanaphylactic hypersensitivity to penicillin and cephalosporin:
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* For life-threatening infections, vancomycin should given every 6 hours. Trough levels of 15 to 20 mcg/mL are suggested for severe infections. For further details, refer to separate UpToDate content on treatment of S. aureus infections in children.
¶ Dose adjustment is necessary for patients with renal impairment. Refer to drug information topics for details.
Δ Experience with these agents in children is limited. Consultation with an infectious diseases specialist is suggested.
◊ Information regarding local susceptibility patterns can be obtained from local public health officials or hospital laboratories. The threshold prevalence of clindamycin-resistant S. aureus for choosing vancomycin varies from center to center, usually ranging from 10 to 25%, in an effort to balance the benefit of definitive therapy for the patient with the risk of increasing vancomycin resistance in the community. For further details, refer to separate UpToDate content on treatment of S. aureus infections in children.