Version July 2025
| Treatment when source is: | |||
| HBsAg positive | HBsAg negative | Not tested or unknown | |
| Vaccination and antibody response status of exposed person | |||
| Unvaccinated | HBIG x 1; initiate HB vaccine series | Initiate HB vaccine series | Initiate HB vaccine series |
| Previously vaccinated | |||
| Known responder | No treatment | No treatment | No treatment |
| Known non-responder | HBIG x 2 or HBIG x 1 and initiate revaccination | No treatment | If known high-risk source, treat as if source were HBsAg positive |
| Antibody response unknown | Test exposed person for anti-HBs | No treatment | Test exposed person for anti-HBs |
| If adequate*, no treatment | If adequate*, no treatment | ||
| If inadequate*, HBIG x 1 and vaccine booster | If inadequate*, initiate revaccination | ||
