Recommended postexposure prophylaxis for percutaneous or permucosal exposure to hepatitis B virus

	Treatment when source is:
	HBsAg positive	HBsAg negative	Not tested or unknown
Vaccination and antibody response status of exposed person
Unvaccinated	HBIG x 1; initiate HB vaccine series	Initiate HB vaccine series	Initiate HB vaccine series
Previously vaccinated
Known responder	No treatment	No treatment	No treatment
Known non-responder	HBIG x 2 or HBIG x 1 and initiate revaccination	No treatment	If known high-risk source, treat as if source were HBsAg positive
Antibody response unknown	Test exposed person for anti-HBs	No treatment	Test exposed person for anti-HBs
	If adequate*, no treatment		If adequate*, no treatment
	If inadequate*, HBIG x 1 and vaccine booster		If inadequate*, initiate revaccination

HBsAg: hepatitis B surface antigen; HBIG: hepatitis B immunoglobulin; HB vaccine series: hepatitis B vaccine; anti-HBs: antibody to hepatitis B surface antigen.
For dosing information see "Hepatitis B immune globulin: Drug information" and "Hepatitis B vaccine: Drug information".

* Responder is defined a person with adequate levels of serum antibody to hepatitis B surface antigen (ie, ≥10 mlU/mL); inadequate response to vaccination defined as serum anti-HBs <10 mlU/mL.

Courtesy of David Weber, MD, MPH.

Graphic 59736 Version 3.0

خرید پکیج

Recommended postexposure prophylaxis for percutaneous or permucosal exposure to hepatitis B virus