Version May 2024
| Therapeutic peak plasma level (h) | Half-life (h), therapeutic | Protein binding (%) | Volume of distribution (L/kg) | Route of metabolism | Active metabolite | |
| Traditional agents | 2 to 5 | 8 to 36 | 90 to 95 | 7 to 62 | CYP2D6 CYP1A2 CYP3A4 | Variable |
| Clozapine | 1 to 4 | 7 to 13 | 92 to 95 | 2 to 5 | CYP1A2 CYP3A4 | Norclozapine |
| Olanzapine | 5 to 6 | 20 to 30 | 93 | 10 to 20 | CYP1A2 CYP2D6 | NO |
| Quetiapine | 1 to 2 | 4 to 10 | 83 | 10 | CYP3A4 | 7-hydroxyquetiapine |
| Risperadone | 1 to 2 | 3 to 24 | 90 | 1 to 1.5 | CYP2D6 | 9-hydroxyrisperidone |
| Ziprasidone | 4 to 5 | 4 to 10 | >99 | 2 | CYP3A4 | NO |
| Aripiprazole | 3 to 5 | 75 to 146 | >99 | 4.9 | CYP2D6 CYP3A4 | Dehydroaripiprazole |
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