May increase INR | May decrease INR | |
Acetaminophen Allopurinol Amiodarone Androgens
Antibiotics
Azole antifungals*
| Cancer therapies
Cholesterol-lowering agents (exception: cholestyramine may decrease the INR)
Cimetidine Glucocorticoids
Omeprazole (case reports with other proton pump inhibitors) Serotonin reuptake inhibitors¶
Sitaxentan (not available in United States) Tramadol | Antibiotics
Azathioprine Cholestyramine Enzyme-inducing antiseizure medications
Ritonavir Saint John's wort Sucralfate Vitamin K |
INR: international normalized ratio; NSAIDs: nonsteroidal anti-inflammatory drugs.
* A more moderate effect on INR control may also be seen with posaconazole and itraconazole.
¶ In addition to potentially increasing the INR, serotonin reuptake inhibitors may also increase bleeding risk by inhibiting platelet reuptake of serotonin.