Oral medications commonly used for spasticity

	Starting dose	Maximum dose	Adverse effects
Baclofen	5 mg, three times daily	120 mg daily, in divided doses	Muscle weakness, sedation, dizziness, withdrawal syndrome
Tizanidine	2 mg daily	36 mg daily in divided doses	Sedation, weakness, dizziness, reversible elevation of transaminase
Diazepam	2 mg twice daily or 5 mg at bedtime	40 to 60 mg daily, in divided doses	Sedation, cognitive impairment, dizziness, potential for dependence and withdrawal syndrome
Dantrolene	25 mg	100 mg, four times daily	Potentially irreversible hepatotoxicity requires regular monitoring, weakness, sedation
Clonidine	0.05 mg, twice daily	0.1 mg, four times daily	Hypotension, bradycardia, dizziness, constipation
Gabapentin	100 mg three times daily	3600 mg daily in divided doses	Sedation, dizziness

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