Vaccine (commercial name) | Carrier protein | Recommended age of administration* | Allergy considerations |
Monovalent Hib vaccines | |||
PRP-OMP¶ (PedvaxHIB) | Outer membrane protein complex of Neisseria meningitidis | 2, 4, and 12 through 15 months | Vial stoppers contain natural rubber latex |
PRP-T (ActHIB) | Tetanus toxoid | 2, 4, 6, and 12 through 15 months | Vial stoppers contain natural rubber latex |
PRP-T (Hiberix) | Tetanus toxoid | 2, 4, 6, and 12 through 15 months | Vial stoppers do not contain natural rubber latex |
Combination Hib vaccine | |||
DTaP-IPV/PRP-T (Pentacel) | Tetanus toxoid | 2, 4, 6, and 15 through 18 monthsΔ | Vial stoppers do not contain natural rubber latex |
DTaP, IPV, Hib, and HepB (Vaxelis) | Outer membrane protein complex of N. meningitidis | 2, 4, and 6 months of age◊ | Vial stoppers do not contain natural rubber latex |
DTaP: diphtheria toxoid-tetanus toxoid-acellular pertussis vaccine; HepB: hepatitis B vaccine; Hib: H. influenzae type b; IPV: inactivated polio vaccine; PRP-OMP: polyribosylribitol phosphate conjugated to outer membrane protein complex of N. meningitidis; PRP-T: polyribosylribitol phosphate conjugated to tetanus toxoid.
* The first dose may be given as early as six weeks of age.
¶ Preferred for Native Americans and Alaskan natives.
Δ The booster (ie, fourth) dose may be given as early as 12 months of age, provided at least six months have elapsed since the third dose of DTaP.
◊ A monovalent Hib vaccine should be used for the booster dose at 12 to 15 months of age.