Drugs that potentiate the action of sulfonylureas

Inhibition of membrane transporters

Clarithromycin, fluoroquinolones (eg, levofloxacin), verapamil

Decreased hepatic CYP2C9 metabolism

Antiinfectives: Fluconazole, metronidazole, isoniazid, miconazole (oral), trimethoprim-sulfamethoxazole (and other sulfonamide antibiotics), voriconazole

Other: Adagrasib, asciminib, amiodarone, cimetidine, fluvastatin, gemfibrozil (and other fibric acid derivatives), mifepristone, nitisinone, omeprazole, warfarin

Intrinsic hypoglycemic activity

Alcohol, androgens (anabolic steroids), beta-blockers (variable effects), bromocriptine, chloroquine, disopyramide, fluoroquinolones, hydroxychloroquine, mecasermin, MAO inhibitors^*, methadone, mifepristone, pentamidine, perhexiline quinine, salicylates^¶, somatostatin analogs (eg, octreotide), sunitinib, tramadol, trimethoprim-sulfamethoxazole (and other sulfonamide antibiotics), other antihyperglycemic drugs

Decreased renal excretion

Probenecid, salicylates^¶

Masks autonomic signs of hypoglycemia

Beta-blockers

Examples of drugs that may potentiate the hypoglycemic effect of sulfonylureas. This is not a complete list. Specific interactions of sulfonylureas may be analyzed by use of the drug interaction program included within UpToDate.

MAO inhibitors: monoamine oxidase inhibitors.

* Examples of MAO inhibitors include: Isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, rasagiline, safinamide, selegiline, Syrian Rue (hallucinogen), tranylcypromine.

¶ Frequently encountered salicylates include: Aspirin, bismuth subsalicylate, salsalate.

Data from: UpToDate Lexidrug. More information available at https://online.lexi.com/.

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Drugs that potentiate the action of sulfonylureas