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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : -3 مورد

Risk factors for chronic and acute recurrent pancreatitis in a cohort of 689 children

Risk factors for chronic and acute recurrent pancreatitis in a cohort of 689 children
Risk category Number of children with risk factor/
number examined for the risk (%)
Family history of chronic pancreatitis 118/555 (21.3)
Genetic
Any mutation 351/535 (65.6)
PRSS1 121/498 (24.3)
SPINK1 104/473 (22)
CFTR 160/483 (33.1)
CTRC 25/378 (6.6)
Obstructive/biliary*
Any obstructive/biliary risk factor 175/667 (26.2)
Pancreas divisum 75/662 (11.3)
Toxic-metabolic
Any toxic-metabolic factor 105/685 (15.3)
Hyperlipidemia (most commonly hypertriglyceridemia) 10/441 (2.3)
Drugs (eg, metronidazole, mercaptopurine, valproate, isoniazid) 49/669 (7.3)
AutoimmuneΔ
Autoimmune disease 65/663 (9.8)
This table shows the proportion of patients with certain risk factors for chronic and acute recurrent pancreatitis from a large multicenter international study. All data were reported from clinically acquired studies; not all patients were evaluated for all risk factors. Some patients may have more than 1 risk factor.

CFTR: cystic fibrosis transmembrane conductance regulator gene; CTRC: chymotrypsin C gene; PRSS1: protease serine 1 gene; SPINK1: serine protease inhibitor Kazal-type 1 gene.

* Other obstructive/biliary risk factors include pancreatobiliary malunion, gallstones, sphincter of Oddi dysfunction, annular pancreas, and other duct obstructions.

¶ Other toxic-metabolic risk factors include active and passive tobacco smoking, alcohol use, and chronic kidney disease.

Δ Autoimmune disease includes autoimmune pancreatitis, other autoimmune factors, autoimmune hepatitis, and inflammatory bowel disease.
Data from: Uc A, Cress GA, Wang F, et al. Analysis of INSPPIRE-2 cohort: Risk factors and disease burden in children with acute recurrent or chronic pancreatitis. J Pediatr Gastroenterol Nutr 2022; 75:643
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