Version June 2024
| Disease | Comments |
| Cutaneous calcinosis | Complication linked to the deposition of calcium. |
| Erythema elevatum diutinum | Rare condition. It may improve in intensity with reduction of the cyclosporine dose. |
| Photosensitivity | Isolated reports: Pseudoporphyria after liver transplantation for congenital biliary atresia, transitory porphyrinemia with light sensitivity in a patient waiting for a second transplantation after necrosis of the hepatic graft. |
| Porokeratosis | Round or oval erythematous plaques with a sharp border. Porokeratosis lesions typically appear four to five years after liver transplantation, and their number varies from one to dozens. These lesions are due to the clonal proliferation of keratinocytes. Porokeratosis in a recipient of a liver transplantation is a sign of a strong immunosuppression. In the context of transplantation, porokeratosis is not a precancerous lesion. |
| Immune thrombocytopenia | Immune thrombocytopenia after liver transplantation can be due to the underlying liver disease (primary biliary cholangitis), an infection (varicella, herpes virus 6, parvovirus B19), the immunosuppression (tacrolimus), or the graft itself. Endogenous heparin-like molecules have been described after liver transplantation and may have a role. |
| Graft-versus-host-disease | Generally rare after transplantation of solid organs, but has been described after liver transplantation. The dermatologic and digestive manifestations are comparable to those observed in graft-versus-host-disease after bone marrow transplantation. The hepatic manifestations are usually mild, probably because the lymphocytes of the donor are immunotolerant to the graft. In the case of acute graft-versus-host-disease, the severity of the dermatologic manifestations range from a maculopapular rash localized to the extremities, to generalized erythroderma and toxic epidermal necrolysis. In the case of chronic graft-versus-host-disease, the lesions are polymorphic with the appearance of lichen planus, scleroderma, ichthyosis, vitiligo, and/or Shulman's fasciitis. Risk factors may include close matching of the donor and recipient HLA types and donor age older than 60 years or younger than 40 years. Fluorescent in situ hybridization can help to reach an early diagnosis in sex mismatched patients. |
| Granuloma annulare | Confluent rash with maculae on sun-exposed areas. |
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