Types of endocrine and nonendocrine autoimmune syndromes associated with adrenal insufficiency

Disorder	Prevalence (%)
Polyglandular autoimmune syndrome type 1
Endocrine
Hypoparathyroidism	89
Chronic mucocutaneous candidiasis	75
Adrenal insufficiency	60
Primary hypogonadism	45
Hypothyroidism	12
Type 1 diabetes mellitus	1
Hypopituitarism	<1
Diabetes insipidus	<1
Nonendocrine
Malabsorption syndromes	25
Alopecia totalis or areata	20
Pernicious anemia	16
Chronic active hepatitis	9
Vitiligo	4
Polyglandular autoimmune syndrome type 2
Endocrine
Adrenal insufficiency	100
Autoimmune thyroid disease	70
Type 1 diabetes mellitus	50
Primary hypogonadism	5 to 50
Diabetes insipidus	<1
Nonendocrine
Vitiligo	4
Alopecia, pernicious anemia, myasthenia gravis, immune thrombocytopenia purpura, Sjögren syndrome, rheumatoid arthritis	≤1

Data from:

Leshin M. Polyglandular autoimmune syndromes. Am J Med Sci 1985; 290:77.
Neufeld M, Maclaren NK, Blizzard RM. Two types of autoimmune Addison's disease associated with different polyglandular autoimmune (PGA) syndromes. Medicine (Baltimore) 1981; 60:355.

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