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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Rates of common morbidities among survivors in selected studies for infants 22 to 25 weeks gestation during the initial NICU admission

Rates of common morbidities among survivors in selected studies for infants 22 to 25 weeks gestation during the initial NICU admission
Study Rate (percent) by gestational week Comment
22 23 24 25 Total
Severe intraventricular hemorrhage (≥grade 3)
NEPS1[1] n/a 11 16 10 12 Infants with CUS* scans at ≥3 weeks
NEPS2[2]  0  14 10  10 CUS before hospital discharge or death
Ishii[3] 24 22 15 12 16  
EXPRESS[4] 20* 19 10 12 13  
Stoll[5] 38 36 26 21 25 Infants with CUS scans within first 28 days
Stoll[6] 35   38 24   17  23 Infants with CUS scans within first 28 days
EPIPAGE[7] NS 0  22  14  16  
Anderson[10] 38  16  13  12 13 

Survival of live births to one year 

Based on ICD-9-CM codes

 

Periventricular leukomalacia
NEPS1[1] n/a 0 14 8 10 Infants with CUS scans at ≥3 weeks
NEPS2[2]  5 3 CUS before hospital discharge or death
Ishii[3] 2.7 4.1 3.9 5.4 4.5  
EXPRESS[4] 0* 9.4 6.2 5.4 6.2  
Stoll[5] 6 4 3 4 4 Infants with CUS scans within first 28 days
Stoll[6] 0 8 5 6 6 Infants with CUS scans within first 28 days
EPIPAGE[7] NS 2 2 3 2  
Anderson[10] 6 3 3 4

Survival of live births to one year 

Based on ICD-9-CM codes

Necrotizing enterocolitis (NEC)
Carlo[8] Both medically and surgically treated NEC
ANS 0 12 10 10 10 ANS subgroup treated with antenatal steroids (ANS)
No ANS 12 15 10 6 9 No ANS subgroup did not receive antenatal steroids
NEPS[1] n/a 0 8.6 0 3 Surgically treated NEC
NEPS[2]  17  9 Bell stages II and III
Ishii[3] 1.4  6.5 3 3.7 4 Both medically and surgically treated NEC
EXPRESS[4] 0* 1.9 9.4 6 6.2 Both medically and surgically treated NEC
Stoll[5] 1.7  8.3 9.2 6.2 7.6 Surgically treated NEC
Stoll[6]  0  16  11  9  11 Bell stages II and III
EPIPAGE[7] NS   100  6  30  

Bell stages II and III

Anderson[10] 14 19 14  11  13

Survival of live births to one year 

Based on ICD-9-CM codes

Bronchopulmonary dysplasia
Carlo[8] Oxygen use at 36 weeks PMA
ANS 65 66 66 55 60 ANS sugroup treated with antenatal steroids (ANS)
No ANS 58 70 54 47 54 No ANS subgroup did not receive antenatal steroids
EPICure[9] n/a   86* 77 70 73 Oxygen use at 36 weeks PMA
NEPS[1] n/a 67 54 47 52 Use of oxygen or assisted ventilation at 36 weeks PMA
NEPS2[2] 67  58  57  34  45  Receipt of ≥30 percent oxygen or respiratory support at 36 weeks PMA
Ishii[3] 21 30 38 34 33 Receipt of ≥30 percent oxygen at 36 weeks PMA
EXPRESS[4]  40 26 31 29 41 Receipt of ≥30 percent oxygen at 36 weeks PMA
Stoll[5] 85 73 69 55 63 Oxygen use at 36 weeks PMA
Stoll[6] 100   89  73 56  66 Oxygen use at 36 weeks PMA or at discharge
EPIPAGE[7]  NS  100  37   28 30 Receipt of 30 percent oxygen and/or mechanical ventilation or continuous positive airway pressure at 36 weeks PMA
Anderson[10] 66 58 53 46 50

Survival of live births to one year 

Based on ICD-9-CM codes

Severe retinopathy of prematurity (ROP)
EPICure[9] n/a 26* 20 10 15 Treated with cryotherapy or laser
NEPS1[1] n/a 33 17 9 14 Treated with cryotherapy
NEPS2[2] 33 34   19 25   ROP ≥Stage 3
Ishii[3] 20 30 31 32 30 Treated with cryotherapy or laser
EXPRESS[4]  80 62 48 32 42 ROP >Stage 2
Stoll[5] 50 40 35 17 27 Infants in hospital at 28 days requiring intervention/surgery
Stoll[6] 25   44 33  18  26  Infants in hospital at 28 days with ROP ≥stage 3
EPIPAGE[7]  NS  0 17  11  ROP ≥Stage 3
Anderson[10] 28 36  26 18 24 

Survival of live births to one year 

ROP requiring surgery, based on ICD-9-CM codes

Late-onset infection
Stoll[5] 58 62 55 46 52 Among infants who survived >3 days after birth
Stoll[6] 29   50  40  31 36  Among infants who survived >3 days after birth
NEPS2[2] 20   23 22  39  29  Among infants who survived >3 days after birth
ANS: antenatal steroid therapy; CUS: cranial ultrasound; ICD-9-CM: International Classification of Diseases, Ninth Revision, Clinical Modification; NICU: Neonatal Intensive Care Unit; NS: No survivors; PMA: postmenstrual age.
* ≤23 weeks.
¶ ≤22 weeks.
References:
  1. Markestad T, Kaaresen PI, Rønnestad A, et al. Early death, morbidity, and need of treatment among extremely premature infants. Pediatrics 2005; 115:1289.
  2. Stensvold HF, Klingenberg C, Stoen R, et al. Neonatal morbidity and 1-year survival of extremely preterm infants. Pediatrics 2017.
  3. Ishii N, Kono Y, Yonemoto N, et al. Outcomes of infants born at 22 and 23 weeks' gestation. Pediatrics 2013; 132:62.
  4. EXPRESS Group, Fellman V, Hellström-Westas L, et al. One-year survival of extremely preterm infants after active perinatal care in Sweden. JAMA 2009; 301:2225.
  5. Stoll BJ, Hansen NI, Bell EF, et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 2010; 126:443.
  6. Stoll BJ, Hansen NI, Bell EF, et al. Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012. JAMA 2015; 314:1039.
  7. Ancel PY, Goffinet F, et al. Survival and morbidity of preterm children born at 22 through 34 weeks’ gestation in France in 2011: Results of the EPIPAGE-2 Cohort Study. JAMA Pediatrics 2015; 169:230.
  8. Carlo WA, McDonald SA, Fanaroff AA, et al. Association of antenatal corticosteroids with mortality and neurodevelopmental outcomes among infants born at 22 to 25 weeks' gestation. JAMA 2011; 306:2348.
  9. Costeloe K, Hennessy E, Gibson AT, et al. The EPICure study: outcomes to discharge from hospital for infants born at the threshold of viability. Pediatrics 2000; 106:659.
  10. Anderson JG, Baer RJ, Partridge JC, et al. Survival and Major Morbidity of Extremely Preterm Infants: A Population-Based Study. Pediatrics 2016; 138:e20154434.
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