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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : -15 مورد

Family history-based estimate of risk

Family history-based estimate of risk
Average risk Moderate risk High risk
  • No known family history
  • or
  • Only 1 second-degree relative (or more distantly related relative) affected
  • 1 first-degree relative with disease onset at an average age
  • or
  • 2 affected second-degree relatives on the same side of the family
  • Premature disease or unusual presentation in a first-degree relative
  • or
  • 2 or more first-degree relatives on the same side of the family affected
  • or
  • 2 or more second-degree relatives on the same side of the family affected, with at least 1 having premature disease onset
  • or
  • 3 or more affected on the same side of the family
  • or
  • Moderate-risk status on both sides of the family
Family history-based risk estimation applies to common, autosomal dominant conditions in adults. Estimations for autosomal recessive and X-linked conditions differ. There are also significant disease-dependent definitions in risk estimation and possible effects of external factors that influence risk, such as diet, smoking, and alcohol use for certain cancers and cardiovascular disease. Refer to UpToDate topics on genetic counseling, genetic testing, and specific conditions for further information and risks associated with those conditions.
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